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Literature DB >> 8042972

Leishmanial glycosomes contain superoxide dismutase.

Abstract

In this work we report that superoxide dismutase is entrapped in a microbody-like organelle, the glycosome, present in Leishmania spp. Studies on the sensitivity of the enzyme to various inhibitors indicated that glycosomal superoxide dismutase is predominantly of the Cu/Zu type. Localization of superoxide dismutase in glycosomes points to the major importance of this organelle in the survival of this pathogen, suggesting a new approach towards chemotherapy for leishmaniasis.

Entities: Disease

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Year: 1994 PMID： 8042972 PMCID： PMC1137081 DOI： 10.1042/bj3010317

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

24 in total

1. Demonstration of Cu-Zn superoxide dismutase in rat liver peroxisomes. Biochemical and immunochemical evidence.

Authors: G S Dhaunsi; S Gulati; A K Singh; J K Orak; K Asayama; I Singh
Journal: J Biol Chem Date: 1992-04-05 Impact factor: 5.157

2. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

Review 3. Glycosomes may provide clues to the import of peroxisomal proteins.

Authors: F R Opperdoes
Journal: Trends Biochem Sci Date: 1988-07 Impact factor: 13.807

Review 4. The glycosome of trypanosomes: properties and biogenesis of a microbody.

Authors: P A Michels
Journal: Exp Parasitol Date: 1989-10 Impact factor: 2.011

5. Superoxide dismutase from Streptococcus mutans. Isolation and characterization of two forms of the enzyme.

Authors: P G Vance; B B Keele; K V Rajagopalan
Journal: J Biol Chem Date: 1972-08-10 Impact factor: 5.157

6. Structural and antigenic characterization of a species- and promastigote-specific Leishmania mexicana amazonensis membrane protein.

Authors: L P Kahl; D McMahon-Pratt
Journal: J Immunol Date: 1987-03-01 Impact factor: 5.422

Review 7. Compartmentation of carbohydrate metabolism in trypanosomes.

Authors: F R Opperdoes
Journal: Annu Rev Microbiol Date: 1987 Impact factor: 15.500

8. An enzyme-based theory of obligate anaerobiosis: the physiological function of superoxide dismutase.

Authors: J M McCord; B B Keele; I Fridovich
Journal: Proc Natl Acad Sci U S A Date: 1971-05 Impact factor: 11.205

9. Cu,Zn superoxide dismutase is a peroxisomal enzyme in human fibroblasts and hepatoma cells.

Authors: G A Keller; T G Warner; K S Steimer; R A Hallewell
Journal: Proc Natl Acad Sci U S A Date: 1991-08-15 Impact factor: 11.205

10. Superoxide dismutases in Eimeria tenella.

Authors: W P Michalski; S J Prowse
Journal: Mol Biochem Parasitol Date: 1991-08 Impact factor: 1.759

5 in total

1. Iron superoxide dismutases targeted to the glycosomes of Leishmania chagasi are important for survival.

Authors: Katherine A Plewes; Stephen D Barr; Lashitew Gedamu
Journal: Infect Immun Date: 2003-10 Impact factor: 3.441

2. Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane.

Authors: N Jabado; A Jankowski; S Dougaparsad; V Picard; S Grinstein; P Gros
Journal: J Exp Med Date: 2000-11-06 Impact factor: 14.307