Literature DB >> 804264

Biological screening in the U.S. Army antimalarial drug development program.

K E Kinnamon, W E Rothe.   

Abstract

The methods of testing drugs in the United States Army Antimalarial Drug Development Program are described. To date over two hundred thousand compounds have been screened. For each 3,000 compounds evaluated in the primary screen, only 1 is assessed for efficacy in the final test system. Of those potential antimalarials assessed in this last system, only about half are deemed worthy of preclinical toxicological evaluation.

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Year:  1975        PMID： 804264     DOI： 10.4269/ajtmh.1975.24.174

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN： 0002-9637            Impact factor:   2.345


  10 in total

Review 1.  Exploiting drug-disease relationships for computational drug repositioning.

Authors:  Joel T Dudley; Tarangini Deshpande; Atul J Butte
Journal:  Brief Bioinform       Date:  2011-06-20       Impact factor: 11.622

2.  Screening procedure using chicks infected with the sporozoites of Plasmodium gallinaceum in an antimalarial drug development programme.

Authors:  K E Kinnamon; D E Davidson; D S Rane
Journal:  Bull World Health Organ       Date:  1985       Impact factor: 9.408

3.  Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique.

Authors:  R E Desjardins; C J Canfield; J D Haynes; J D Chulay
Journal:  Antimicrob Agents Chemother       Date:  1979-12       Impact factor: 5.191

4.  A new in vivo screening paradigm to accelerate antimalarial drug discovery.

Authors:  María Belén Jiménez-Díaz; Sara Viera; Javier Ibáñez; Teresa Mulet; Noemí Magán-Marchal; Helen Garuti; Vanessa Gómez; Lorena Cortés-Gil; Antonio Martínez; Santiago Ferrer; María Teresa Fraile; Félix Calderón; Esther Fernández; Leonard D Shultz; Didier Leroy; David M Wilson; José Francisco García-Bustos; Francisco Javier Gamo; Iñigo Angulo-Barturen
Journal:  PLoS One       Date:  2013-06-25       Impact factor: 3.240

5.  Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta).

Authors:  Geoffrey S Dow; Montip Gettayacamin; Pranee Hansukjariya; Rawiwan Imerbsin; Srawuth Komcharoen; Jetsumon Sattabongkot; Dennis Kyle; Wilbur Milhous; Simon Cozens; David Kenworthy; Anne Miller; Jim Veazey; Colin Ohrt
Journal:  Malar J       Date:  2011-07-29       Impact factor: 2.979

6.  Network-based inference methods for drug repositioning.

Authors:  Hailin Chen; Heng Zhang; Zuping Zhang; Yiqin Cao; Wenliang Tang
Journal:  Comput Math Methods Med       Date:  2015-04-12       Impact factor: 2.238

7.  A miRNA-driven inference model to construct potential drug-disease associations for drug repositioning.

Authors:  Hailin Chen; Zuping Zhang
Journal:  Biomed Res Int       Date:  2015-02-19       Impact factor: 3.411

8.  Semantic Web Ontology and Data Integration: a Case Study in Aiding Psychiatric Drug Repurposing.

Authors:  Chen Liang; Jingchun Sun; Cui Tao
Journal:  AMIA Jt Summits Transl Sci Proc       Date:  2016-07-20

9.  Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds.

Authors:  Gregory J Crowther; Heidi K Hillesland; Katelyn R Keyloun; Molly C Reid; Maria Jose Lafuente-Monasterio; Sonja Ghidelli-Disse; Stephen E Leonard; Panqing He; Jackson C Jones; Mallory M Krahn; Jack S Mo; Kartheek S Dasari; Anna M W Fox; Markus Boesche; Majida El Bakkouri; Kasey L Rivas; Didier Leroy; Raymond Hui; Gerard Drewes; Dustin J Maly; Wesley C Van Voorhis; Kayode K Ojo
Journal:  PLoS One       Date:  2016-03-02       Impact factor: 3.240

10.  Antiparasitic and disease-modifying activity of Nyctanthes arbor-tristis Linn. in malaria: An exploratory clinical study.

Authors:  Chhaya S Godse; Prakash S Tathed; Sameer S Talwalkar; Rama A Vaidya; Ashok J Amonkar; Akhil B Vaidya; Ashok D B Vaidya
Journal:  J Ayurveda Integr Med       Date:  2016-11-30
  10 in total

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