| Literature DB >> 8042482 |
L Nordsletten1, J E Madsen, R Almaas, T Rootwelt, J Halse, Y T Konttinen, M Hukkanen, S Santavirta.
Abstract
The effect of sciatic nerve resection on tibial fracture healing was studied in rats 25 days post-trauma. To prevent differences in loading between sham-operated and nerve-resected animals the fractured limbs were cast-immobilized. On radiograms 8 of 11 fractures in the sham-operated animals showed very little callus formation in contrast to only 1 of 8 fractures in the group with nerve resection. Measured by single-photon absorptiometry, animals with sciatic nerve resection had a higher bone mineral content than the sham-operated animals. However, the mechanical strength in three-point cantilever bending was not better in the nerve-resected rats, implying a defective organization of the large callus. These results suggest neural regulation plays a role in the type of fracture healing, primary or secondary, and in the amount and quality of the callus.Entities:
Mesh：
Year: 1994 PMID： 8042482 DOI： 10.3109/17453679408995457
Source DB: PubMed Journal: Acta Orthop Scand ISSN： 0001-6470