Literature DB >> 8041608

Prediction of an rRNA methyltransferase domain in human tumor-specific nucleolar protein P120.

E V Koonin1.   

Abstract

Using computer methods for identification of amino acid motifs in sequence databases and multiple alignment, it is shown that human proliferation-associated nucleolar protein P120 contains a putative methyltransferase domain that is conserved in a group of bacterial proteins. It is hypothesized that P120 and the related prokaryotic proteins are rRNA methylases required for division of all types of cells.

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Year:  1994        PMID： 8041608      PMCID： PMC308198          DOI： 10.1093/nar/22.13.2476

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  22 in total

Review 1.  The final common pathway of cancer.

Authors:  H Busch
Journal:  Cancer Res       Date:  1990-08-15       Impact factor: 12.701

2.  Cloning of the cDNA and sequence of the human proliferating-cell nucleolar protein P120.

Authors:  A Fonagy; D Henning; S Jhiang; M Haidar; R K Busch; R Larson; B Valdez; H Busch
Journal:  Cancer Commun       Date:  1989

3.  Isolation and characterization of a nucleolar 2'-O-methyltransferase from Ehrlich ascites tumor cells.

Authors:  D C Eichler; N K Raber; C M Shumard; S J Eales
Journal:  Biochemistry       Date:  1987-03-24       Impact factor: 3.162

4.  Characterization and cloning of the gerC locus of Bacillus subtilis 168.

Authors:  M A Yazdi; A Moir
Journal:  J Gen Microbiol       Date:  1990-07

5.  mRNA levels for human nucleolar protein P120 in tumor and nontumor cells.

Authors:  J Hazlewood; A Fonagy; D Henning; J W Freeman; R K Busch; H Busch
Journal:  Cancer Commun       Date:  1989

6.  Gene sequence tags from Plasmodium falciparum genomic DNA fragments prepared by the "genease" activity of mung bean nuclease.

Authors:  G R Reddy; D Chakrabarti; S M Schuster; R J Ferl; E C Almira; J B Dame
Journal:  Proc Natl Acad Sci U S A       Date:  1993-11-01       Impact factor: 11.205

7.  Growth inhibition of human tumor cell lines by antisense oligonucleotides designed to inhibit p120 expression.

Authors:  L Perlaky; Y Saijo; R K Busch; C F Bennett; C K Mirabelli; S T Crooke; H Busch
Journal:  Anticancer Drug Des       Date:  1993-02

8.  Computer-assisted identification of a putative methyltransferase domain in NS5 protein of flaviviruses and lambda 2 protein of reovirus.

Authors:  E V Koonin
Journal:  J Gen Virol       Date:  1993-04       Impact factor: 3.891

9.  Sequence of the D-aspartyl/L-isoaspartyl protein methyltransferase from human erythrocytes. Common sequence motifs for protein, DNA, RNA, and small molecule S-adenosylmethionine-dependent methyltransferases.

Authors:  D Ingrosso; A V Fowler; J Bleibaum; S Clarke
Journal:  J Biol Chem       Date:  1989-11-25       Impact factor: 5.157

10.  An NTP-binding motif is the most conserved sequence in a highly diverged monophyletic group of proteins involved in positive strand RNA viral replication.

Authors:  A E Gorbalenya; V M Blinov; A P Donchenko; E V Koonin
Journal:  J Mol Evol       Date:  1989-03       Impact factor: 2.395
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  11 in total

Review 1.  Protein trans-acting factors involved in ribosome biogenesis in Saccharomyces cerevisiae.

Authors:  D Kressler; P Linder; J de La Cruz
Journal:  Mol Cell Biol       Date:  1999-12       Impact factor: 4.272

2.  Exposition of a family of RNA m(5)C methyltransferases from searching genomic and proteomic sequences.

Authors:  R Reid; P J Greene; D V Santi
Journal:  Nucleic Acids Res       Date:  1999-08-01       Impact factor: 16.971

3.  Detection of conserved segments in proteins: iterative scanning of sequence databases with alignment blocks.

Authors:  R L Tatusov; S F Altschul; E V Koonin
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-06       Impact factor: 11.205

4.  Multisite-specific tRNA:m5C-methyltransferase (Trm4) in yeast Saccharomyces cerevisiae: identification of the gene and substrate specificity of the enzyme.

Authors:  Y Motorin; H Grosjean
Journal:  RNA       Date:  1999-08       Impact factor: 4.942

5.  Temperature sensitive nop2 alleles defective in synthesis of 25S rRNA and large ribosomal subunits in Saccharomyces cerevisiae.

Authors:  B Hong; K Wu; J S Brockenbrough; P Wu; J P Aris
Journal:  Nucleic Acids Res       Date:  2001-07-15       Impact factor: 16.971

6.  Nop2p is required for pre-rRNA processing and 60S ribosome subunit synthesis in yeast.

Authors:  B Hong; J S Brockenbrough; P Wu; J P Aris
Journal:  Mol Cell Biol       Date:  1997-01       Impact factor: 4.272

7.  Efficacy of p120 antisense-mediated therapy for pancreatic cancer.

Authors:  J W Freeman; W E Strodel; P C McGrath
Journal:  J Gastrointest Surg       Date:  1997 Sep-Oct       Impact factor: 3.452

8.  Sequence similarity analysis of Escherichia coli proteins: functional and evolutionary implications.

Authors:  E V Koonin; R L Tatusov; K E Rudd
Journal:  Proc Natl Acad Sci U S A       Date:  1995-12-05       Impact factor: 11.205

9.  A conserved motif in the yeast nucleolar protein Nop2p contains an essential cysteine residue.

Authors:  M King; D Ton; K L Redman
Journal:  Biochem J       Date:  1999-01-01       Impact factor: 3.857

Review 10.  5-methylcytosine in RNA: detection, enzymatic formation and biological functions.

Authors:  Yuri Motorin; Frank Lyko; Mark Helm
Journal:  Nucleic Acids Res       Date:  2009-12-08       Impact factor: 16.971
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