Literature DB >> 8041520

Calpeptin, a calpain inhibitor, promotes neurite elongation in differentiating PC12 cells.

M Pintér1, A Aszódi, P Friedrich, I Ginzburg.   

Abstract

Calpain activity of nerve growth factor (NGF)-induced rat pheochromocytoma (PC12) cells shows a transient diminution in the early phase of differentiation. Calpain activity can be further decreased by a cell-permeable calpain inhibitor, calpeptin, which enhances the effect of NGF by stimulating neurite elongation. The number of neurites sprouted by one cell is not increased by calpeptin. A possible role of calpain inhibition during PC12 cells' early differentiation is discussed.

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Year:  1994        PMID： 8041520     DOI： 10.1016/0304-3940(94)90246-1

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  10 in total

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Journal:  Arch Biochem Biophys       Date:  2011-12-09       Impact factor: 4.013

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Review 3.  The pathogenic activation of calpain: a marker and mediator of cellular toxicity and disease states.

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5.  Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation.

Authors:  Daniela M Santos; Joana M Xavier; Ana L Morgado; Susana Solá; Cecília M P Rodrigues
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Journal:  Pathogens       Date:  2019-08-15

8.  Varicones and growth cones: two neurite terminals in PC12 cells.

Authors:  Ana Mingorance-Le Meur; Alma N Mohebiany; Timothy P O'Connor
Journal:  PLoS One       Date:  2009-02-02       Impact factor: 3.240

9.  Critical role of astrocytic interleukin-17 A in post-stroke survival and neuronal differentiation of neural precursor cells in adult mice.

Authors:  Y Lin; J-C Zhang; C-Y Yao; Y Wu; A F Abdelgawad; S-L Yao; S-Y Yuan
Journal:  Cell Death Dis       Date:  2016-06-23       Impact factor: 8.469

10.  Alpha 7 nicotinic receptors attenuate neurite development through calcium activation of calpain at the growth cone.

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Journal:  PLoS One       Date:  2018-05-16       Impact factor: 3.240
  10 in total

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