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Literature DB >> 8040090

Lipid peroxidation inhibitor attenuates noise-induced temporary threshold shifts.

W S Quirk¹, B G Shivapuja, C L Schwimmer, M D Seidman.

Abstract

The purpose of this study was to investigate the protective effects of U74389F (Upjohn Co. Kalamazoo, MI), a 21-aminosteroid/lipid peroxidation inhibitor, and a member of the lazaroid drug class, on temporary threshold shifts in animals exposed to prolonged noise stimulation. Animals treated with U74389F and exposed to noise showed attenuated cochlear action potential threshold (CAP) shifts and cochlear microphonic (CM) when compared to non-drug treated noise-exposed subjects. These data suggest that inhibition of FOR induced lipid peroxidation is an important mechanism in noise-induced asymptotic temporary threshold shifts.

Entities: Chemical

Mesh：

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Year: 1994 PMID： 8040090 DOI： 10.1016/0378-5955(94)90189-9

Source DB: PubMed Journal: Hear Res ISSN： 0378-5955 Impact factor: 3.208

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Cited

12 in total

1. Current aspects of hearing loss from occupational and leisure noise.

Authors: S Plontke; H-P Zenner
Journal: GMS Curr Top Otorhinolaryngol Head Neck Surg Date: 2004-12-28

2. Effects of antioxidants on auditory nerve function and survival in deafened guinea pigs.

Authors: Jun Maruyama; Takahiko Yamagata; Mats Ulfendahl; Göran Bredberg; Richard A Altschuler; Josef M Miller
Journal: Neurobiol Dis Date: 2006-11-16 Impact factor: 5.996

Review 3. Mechanisms of noise-induced hearing loss indicate multiple methods of prevention.

Authors: Colleen G Le Prell; Daisuke Yamashita; Shujiro B Minami; Tatsuya Yamasoba; Josef M Miller
Journal: Hear Res Date: 2006-12-04 Impact factor: 3.208

4. Free radical scavengers vitamins A, C, and E plus magnesium reduce noise trauma.

Authors: Colleen G Le Prell; Larry F Hughes; Josef M Miller
Journal: Free Radic Biol Med Date: 2007-02-20 Impact factor: 7.376

5. Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation.

Authors: U Pirvola; L Xing-Qun; J Virkkala; M Saarma; C Murakata; A M Camoratto; K M Walton; J Ylikoski
Journal: J Neurosci Date: 2000-01-01 Impact factor: 6.167

Lipid peroxidation inhibitor attenuates noise-induced temporary threshold shifts.

1. Current aspects of hearing loss from occupational and leisure noise.

2. Effects of antioxidants on auditory nerve function and survival in deafened guinea pigs.

Review 3. Mechanisms of noise-induced hearing loss indicate multiple methods of prevention.

4. Free radical scavengers vitamins A, C, and E plus magnesium reduce noise trauma.

5. Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation.

6. Damage and threshold shift resulting from cochlear exposure to paraquat-generated superoxide.

7. Protection from impulse noise-induced hearing loss with novel Src-protein tyrosine kinase inhibitors.

8. Acrylonitrile potentiates noise-induced hearing loss in rat.

9. Cellular glutathione content in the organ of Corti and its role during ototoxicity.

10. Protective effect of silymarin on noise-induced hearing loss in Guinea pigs.