BACKGROUND: Solar/actinic keratoses (AKS) are premalignant lesions, usually less than 1 cm in diameter, that appear on chronically sun-damaged skin. METHODS: We describe four patients with a form of AK that enlarged and recurred despite standard treatment. Histologic examination revealed a single and multilayered sheet of anaplastic cells along the undersurface of the epidermis extending down hair follicles and present over a large area. RESULTS: Three of the patients developed either a squamous cell carcinoma (SCC) or basal cell carcinoma (BCC) within the area encompassed by the AK. CONCLUSIONS: These cases represent an insidious, proliferative form of AK with an increased tendency to develop into skin cancer.
BACKGROUND: Solar/actinic keratoses (AKS) are premalignant lesions, usually less than 1 cm in diameter, that appear on chronically sun-damaged skin. METHODS: We describe four patients with a form of AK that enlarged and recurred despite standard treatment. Histologic examination revealed a single and multilayered sheet of anaplastic cells along the undersurface of the epidermis extending down hair follicles and present over a large area. RESULTS: Three of the patients developed either a squamous cell carcinoma (SCC) or basal cell carcinoma (BCC) within the area encompassed by the AK. CONCLUSIONS: These cases represent an insidious, proliferative form of AK with an increased tendency to develop into skin cancer.
Authors: Alejandro Garcia-Uribe; Jun Zou; Madeleine Duvic; Jeong Hee Cho-Vega; Victor G Prieto; Lihong V Wang Journal: Cancer Res Date: 2012-04-05 Impact factor: 12.701