Literature DB >> 8039723

Cloning and sequencing of the cDNA encoding a human testis phospholipid hydroperoxide glutathione peroxidase.

R S Esworthy1, K Doan, J H Doroshow, F F Chu.   

Abstract

A human cDNA that encodes a polypeptide that has 94% deduced amino-acid sequence identity to porcine phospholipid hydroperoxide glutathione peroxidase was cloned from a testis library. The sequence shows preservation of the UGA selenocysteine codon, putative active-site Trp and Glu residues and a Tyr residue that is phosphorylated in the porcine protein. The 3'-UTR shows some conservation of sequences implicated in the insertion of selenocysteine at an opal codon in human glutathione peroxidase-1.

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Year:  1994        PMID： 8039723     DOI： 10.1016/0378-1119(94)90400-6

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  11 in total

1.  In vitro evolution of horse heart myoglobin to increase peroxidase activity.

Authors:  L Wan; M B Twitchett; L D Eltis; A G Mauk; M Smith
Journal:  Proc Natl Acad Sci U S A       Date:  1998-10-27       Impact factor: 11.205

2.  A novel type of glutathione peroxidase: expression and regulation during wound repair.

Authors:  B Munz; S Frank; G Hübner; E Olsen; S Werner
Journal:  Biochem J       Date:  1997-09-01       Impact factor: 3.857

Review 3.  Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities.

Authors:  Edith Lubos; Joseph Loscalzo; Diane E Handy
Journal:  Antioxid Redox Signal       Date:  2011-04-10       Impact factor: 8.401

4.  An RNA-binding protein recognizes a mammalian selenocysteine insertion sequence element required for cotranslational incorporation of selenocysteine.

Authors:  A Lesoon; A Mehta; R Singh; G M Chisolm; D M Driscoll
Journal:  Mol Cell Biol       Date:  1997-04       Impact factor: 4.272

Review 5.  The beginning of GPX2 and 30 years later.

Authors:  R Steven Esworthy; James H Doroshow; Fong-Fong Chu
Journal:  Free Radic Biol Med       Date:  2022-07-05       Impact factor: 8.101

6.  Cloning, characterization, and expression analysis of goat (Capra hircus) phospholipid hydroperoxide glutathione peroxidase (PHGPx).

Authors:  Li-guang Shi; Wen-juan Xun; Wen-bin Yue; Chun-xiang Zhang; You-she Ren; Qian Wang; Xiao-ying Wu; Lei Shi; Ru-jie Yang; Fu-lin Lei
Journal:  Int J Biol Sci       Date:  2010-06-10       Impact factor: 6.580

7.  Puberty influences expression of phospholipid hydroperoxide glutathione peroxidase (GPX4) in rat testis: probable hypophysis regulation of the enzyme in male reproductive tract.

Authors:  A Giannattasio; M Girotti; K Williams; L Hall; A Bellastella
Journal:  J Endocrinol Invest       Date:  1997-09       Impact factor: 4.256

8.  Effect of myomectomy on endometrial glutathione peroxidase 3 (GPx3) and glycodelin mRNA expression at the time of the implantation window.

Authors:  Marzieh Farimani Sanoee; Tahereh Alizamir; Shamila Faramarzi; Massoud Saidijam; Reza Yadegarazari; Nooshin Shabab; Alireza Rastgoo Haghi; Zohreh Alizadeh
Journal:  Iran Biomed J       Date:  2014

9.  Novel enrichment of tumor cell transfectants expressing high levels of type 4 glutathione peroxidase using 7alpha-hydroperoxycholesterol as a selection agent.

Authors:  Tamas Kriska; Vladislav V Levchenko; Fong-Fong Chu; R Steven Esworthy; Albert W Girotti
Journal:  Free Radic Biol Med       Date:  2008-06-03       Impact factor: 7.376

10.  The Roles of Glutathione Peroxidases during Embryo Development.

Authors:  Christoph Ufer; Chi Chiu Wang
Journal:  Front Mol Neurosci       Date:  2011-07-28       Impact factor: 5.639
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