| Literature DB >> 8038519 |
H Naitoh1, S Yazawa, T Asao, T Nakajima, J Nakamura, S Takenoshita, Y Nagamachi.
Abstract
A monoclonal antibody, YB-2, which has a novel epitope for fucosylated antigens and shows cross-reactivity with Y/Leb/H type 2 antigens, was used in an immunohistochemical study of human neoplastic and normal colorectal tissues. Of 64 colorectal cancers, 59 (92.2%) were stained by the YB-2 antibody; however, only 3 (12.0%) of 25 samples of normal colon mucosa and 13 (50.0%) of 26 adenomas expressed the antigens recognized by YB-2. Clinicopathologically, the YB-2-negative colon cancers were exclusively in Dukes stage A. These results indicate that the monoclonal antibody, YB-2, could detect cancer-associated antigens, and the degree of YB-2-reacted antigen expression might be correlated with the progression of colorectal carcinogenesis.Entities:
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Year: 1994 PMID： 8038519 DOI： 10.1007/bf02348574
Source DB: PubMed Journal: Surg Today ISSN： 0941-1291 Impact factor: 2.549