Literature DB >> 8038225

Various factors influencing the signal intensity of oligonucleotides in electrospray mass spectrometry.

K Bleicher1, E Bayer.   

Abstract

The quality of electrospray mass spectra of oligonucleotides often suffers from the low signal intensity and clustering with metal ions. This sometimes makes an exact determination of the molecular masses impossible. We describe here several factors contributing to these effects and show some means for their improvement.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 8038225     DOI： 10.1002/bms.1200230604

Source DB:  PubMed          Journal:  Biol Mass Spectrom        ISSN： 1052-9306


  14 in total

1.  Mononucleotide gas-phase proton affinities as determined by the kinetic method.

Authors:  K B Green-Church; P A Limbach
Journal:  J Am Soc Mass Spectrom       Date:  2000-01       Impact factor: 3.109

2.  Assessing the Interplay between the Physicochemical Parameters of Ion-Pairing Reagents and the Analyte Sequence on the Electrospray Desorption Process for Oligonucleotides.

Authors:  Babak Basiri; Mandi M Murph; Michael G Bartlett
Journal:  J Am Soc Mass Spectrom       Date:  2017-04-12       Impact factor: 3.109

3.  Charge-state reduction with improved signal intensity of oligonucleotides in electrospray ionization mass spectrometry.

Authors:  D C Muddiman; X Cheng; H R Udseth; R D Smith
Journal:  J Am Soc Mass Spectrom       Date:  1996-08       Impact factor: 3.109

4.  Verification of 50- to 100-mer DNA and RNA sequences with high-resolution mass spectrometry.

Authors:  D P Little; T W Thannhauser; F W McLafferty
Journal:  Proc Natl Acad Sci U S A       Date:  1995-03-14       Impact factor: 11.205

5.  Phosphorothioate oligonucleotide quantification by μ-liquid chromatography-mass spectrometry.

Authors:  Robert Erb; Katharina Leithner; Andreas Bernkop-Schnürch; Herbert Oberacher
Journal:  AAPS J       Date:  2012-07-18       Impact factor: 4.009

6.  Diisopropylethylamine/hexafluoroisopropanol-mediated ion-pairing ultra-high-performance liquid chromatography/mass spectrometry for phosphate and carboxylate metabolite analysis: utility for studying cellular metabolism.

Authors:  Lili Guo; Andrew J Worth; Clementina Mesaros; Nathaniel W Snyder; Jerry D Glickson; Ian A Blair
Journal:  Rapid Commun Mass Spectrom       Date:  2016-08-30       Impact factor: 2.419

7.  Parallel minisequencing followed by multiplex matrix-assisted laser desorption/ionization mass spectrometry assay for beta-thalassemia mutations.

Authors:  Hsin-Kai Liao; Yi-Ning Su; Hung-Yi Kao; Chia-Cheng Hung; Hsueh-Ting Wang; Yu-Ju Chen
Journal:  J Hum Genet       Date:  2005-03-11       Impact factor: 3.172

8.  The effect of organic modifiers on electrospray ionization charge-state distribution and desorption efficiency for oligonucleotides.

Authors:  Buyun Chen; Sadie F Mason; Michael G Bartlett
Journal:  J Am Soc Mass Spectrom       Date:  2013-01-17       Impact factor: 3.109

9.  Negative electrospray ionization mass spectrometry of synthetic and chemically modified oligonucleotides.

Authors:  N Potier; A Van Dorsselaer; Y Cordier; O Roch; R Bischoff
Journal:  Nucleic Acids Res       Date:  1994-09-25       Impact factor: 16.971

10.  Investigation of the 'n-1' impurity in phosphorothioate oligodeoxynucleotides synthesized by the solid-phase beta-cyanoethyl phosphoramidite method using stepwise sulfurization.

Authors:  K L Fearon; J T Stults; B J Bergot; L M Christensen; A M Raible
Journal:  Nucleic Acids Res       Date:  1995-07-25       Impact factor: 16.971
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.