Literature DB >> 8037723

Role of extracellular matrix in wound repair by cultured gastric mucosal cells.

H Mikami1, S Watanabe, M Hirose, N Sato.   

Abstract

Effects of extracellular matrix on wound repair of cultured gastric epithelial cells were assessed. Artificial wounds were made by mechanical cell denudation in confluent rabbit gastric epithelial cell sheets which were formed on different types of extracellular matrix (e.g., collagen type I and type IV, laminin, fibronectin and Matrigel). Changes in wound size were analyzed quantitatively. Cell migration and proliferation were observed in stages of the wound repair process. The speed of wound repair was different with each extracellular matrix studied and was fastest on Matrigel. The type of extracellular matrix used in this study modulated both cell migration and proliferation. Therefore, it is concluded that extracellular matrix plays an important role in rates of gastric mucosal wound healing.

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Year:  1994        PMID： 8037723     DOI： 10.1006/bbrc.1994.1925

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  10 in total

1.  Effect of Helicobacter pylori on gastric epithelial cell migration and proliferation in vitro: role of VacA and CagA.

Authors:  V Ricci; C Ciacci; R Zarrilli; P Sommi; M K Tummuru; C Del Vecchio Blanco; C B Bruni; T L Cover; M J Blaser; M Romano
Journal:  Infect Immun       Date:  1996-07       Impact factor: 3.441

2.  Gastric ulcer healing in the rat: kinetics and localisation of de novo procollagen synthesis.

Authors:  M Shahin; A Gillessen; T Pohle; C Weber; D Schuppan; H Herbst; W Domschke
Journal:  Gut       Date:  1997-08       Impact factor: 23.059

3.  Ethanol retards gastric epithelial restoration in monolayer cultures.

Authors:  T Murai; S Watanabe; M Hirose; H Miwa; A Miyazaki; N Sato
Journal:  Dig Dis Sci       Date:  1996-10       Impact factor: 3.199

4.  Effect of mechanical strain on gastric cellular migration and proliferation during mucosal healing: role of Rho dependent and Rac dependent cytoskeletal reorganisation.

Authors:  T Osada; S Watanabe; H Tanaka; M Hirose; A Miyazaki; N Sato
Journal:  Gut       Date:  1999-10       Impact factor: 23.059

5.  Expression of type I and IV collagen mRNAs in healing gastric ulcers--a comparative analysis using isotopic and non-radioactive in situ hybridization.

Authors:  T Pohle; M Shahin; A Gillessen; D Schuppan; H Herbst; W Domschke
Journal:  Histochem Cell Biol       Date:  1996-10       Impact factor: 4.304

6.  Effect of growth factors and prostaglandin E2 on restitution and proliferation of rabbit esophageal epithelial cells.

Authors:  P Jimenez; A Lanas; E Piazuelo; F Esteva
Journal:  Dig Dis Sci       Date:  1998-10       Impact factor: 3.199

7.  Differential expression of laminin chains and their integrin receptors in human gastric mucosa.

Authors:  I Virtanen; T Tani; N Bäck; O Häppölä; L Laitinen; T Kiviluoto; J Salo; R E Burgeson; V P Lehto; E Kivilaakso
Journal:  Am J Pathol       Date:  1995-10       Impact factor: 4.307

8.  In vitro wound repair by human gastric fibroblasts: implications for ulcer healing.

Authors:  E Piazuelo; A Lanas; P Jimenez; A García-Gonzalez; F Esteva
Journal:  Dig Dis Sci       Date:  1998-06       Impact factor: 3.199

9.  Matrigel increases the rate of split wound healing and promotes keratinocyte ;take' in deep wounds in rats.

Authors:  J V Gorelik; B A Paramonov; M I Blinova; I A Diakonov; L V Kukhareva; G P Pinaev
Journal:  Cytotechnology       Date:  2000-02       Impact factor: 2.058

10.  In vitro vitamin K3 effect on conjunctival fibroblast migration and proliferation.

Authors:  I Pinilla; L B Izaguirre; F J Gonzalvo; E Piazuelo; M A Garcia-Gonzalez; A I Sanchez-Cano; F Sopeña
Journal:  ScientificWorldJournal       Date:  2014-01-08
  10 in total

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