Literature DB >> 8037663

O-glycosidically linked N-acetylglucosamine-bound oligosaccharides from glycoproteins of Trypanosoma cruzi.

J O Previato1, C Jones, L P Gonçalves, R Wait, L R Travassos, L Mendonça-Previato.   

Abstract

In this report we describe studies on the structures of the O-linked carbohydrate units in cell-surface glycoproteins of epimastigote forms of the G-strain of Trypanosoma cruzi. Mild alkaline reductive degradation of the 38/43 kDa glycoproteins resulted in beta-elimination of glycosylated threonine and/or serine residues, and the liberation of N-acetylglucosaminitol, galactobiosyl-, galactotriosyl-, galactotetraosyl- and galactopentaosyl-N-acetylglucosaminitol. The structures of these oligosaccharide alditols were established by n.m.r. spectroscopy and methylation analysis as: Galf beta 1-4(Galp beta 1-6)GlcNAc-ol; Galp beta 1-3Galp beta 1-6(Galf beta 1-4)GlcNAc-ol; [(Galp beta 1-3)(Galp beta 1-2)Galp beta 1-6](Galf beta 1-4)GlcNAc-ol; [(Galp beta 1-3)(Galp beta 1-2)Galp beta 1-6](Galp beta 1-2Galf beta 1-4)GlcNAc-ol.

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Year:  1994        PMID： 8037663      PMCID： PMC1137155          DOI： 10.1042/bj3010151

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  32 in total

Review 1.  Glycosylation of nuclear and cytoplasmic proteins is ubiquitous and dynamic.

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Review 2.  F.A.B.-mass spectrometry of carbohydrates.

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3.  The 35/50 kDa surface antigen of Trypanosoma cruzi metacyclic trypomastigotes, an adhesion molecule involved in host cell invasion.

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Authors:  S Schenkman; M S Jiang; G W Hart; V Nussenzweig
Journal:  Cell       Date:  1991-06-28       Impact factor: 41.582

5.  Complement-mediated lysis of Trypanosoma cruzi trypomastigotes by human anti-alpha-galactosyl antibodies.

Authors:  I C Almeida; S R Milani; P A Gorin; L R Travassos
Journal:  J Immunol       Date:  1991-04-01       Impact factor: 5.422

6.  Structure of the glycosyl-phosphatidylinositol membrane anchor of the Leishmania major promastigote surface protease.

Authors:  P Schneider; M A Ferguson; M J McConville; A Mehlert; S W Homans; C Bordier
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7.  Topology of O-linked N-acetylglucosamine in murine lymphocytes.

Authors:  K P Kearse; G W Hart
Journal:  Arch Biochem Biophys       Date:  1991-11-01       Impact factor: 4.013

8.  Application of new, high-sensitivity, 1H-13C-n.m.r.-spectral techniques to the study of oligosaccharides.

Authors:  L Lerner; A Bax
Journal:  Carbohydr Res       Date:  1987-08-15       Impact factor: 2.104

9.  Substrate specificity of the Trypanosoma cruzi trans-sialidase.

Authors:  F Vandekerckhove; S Schenkman; L Pontes de Carvalho; S Tomlinson; M Kiso; M Yoshida; A Hasegawa; V Nussenzweig
Journal:  Glycobiology       Date:  1992-12       Impact factor: 4.313

10.  The action of Trypanosoma cruzi trans-sialidase on glycolipids and glycoproteins.

Authors:  M A Ferrero-García; S E Trombetta; D O Sánchez; A Reglero; A C Frasch; A J Parodi
Journal:  Eur J Biochem       Date:  1993-04-15
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  25 in total

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Journal:  Biochem J       Date:  2000-02-01       Impact factor: 3.857

2.  Proinflammatory and cytotoxic effects of hexadecylphosphocholine (miltefosine) against drug-resistant strains of Trypanosoma cruzi.

Authors:  Victor B Saraiva; Daniel Gibaldi; José O Previato; Lucia Mendonça-Previato; Marcelo T Bozza; Célio G Freire-De-Lima; Norton Heise
Journal:  Antimicrob Agents Chemother       Date:  2002-11       Impact factor: 5.191

Review 3.  The intersections between O-GlcNAcylation and phosphorylation: implications for multiple signaling pathways.

Authors:  Quira Zeidan; Gerald W Hart
Journal:  J Cell Sci       Date:  2010-01-01       Impact factor: 5.285

4.  The nematode Caenorhabditis elegans synthesizes unusual O-linked glycans: identification of glucose-substituted mucin-type O-glycans and short chondroitin-like oligosaccharides.

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5.  Effects of platelet-activating factor on the interaction of Trypanosoma cruzi with Rhodnius prolixus.

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Journal:  Parasitol Res       Date:  2010-12-14       Impact factor: 2.289

6.  Structural variation in the glycoinositolphospholipids of different strains of Trypanosoma cruzi.

Authors:  J C Carreira; C Jones; R Wait; J O Previato; L Mendonça-Previato
Journal:  Glycoconj J       Date:  1996-12       Impact factor: 2.916

7.  Golgi UDP-GlcNAc:polypeptide O-α-N-Acetyl-d-glucosaminyltransferase 2 (TcOGNT2) regulates trypomastigote production and function in Trypanosoma cruzi.

Authors:  Carolina M Koeller; Hanke van der Wel; Christa L Feasley; Fernanda Abreu; Juliana Dutra Barbosa da Rocha; Fabrício Montalvão; Patrícia Fampa; Flávia C G Dos Reis; Georgia C Atella; Thaís Souto-Padrón; Christopher M West; Norton Heise
Journal:  Eukaryot Cell       Date:  2014-08-01

8.  Fate of glycosylphosphatidylinositol (GPI)-less procyclin and characterization of sialylated non-GPI-anchored surface coat molecules of procyclic-form Trypanosoma brucei.

Authors:  Maria Lucia Sampaio Güther; Kenneth Beattie; Douglas J Lamont; John James; Alan R Prescott; Michael A J Ferguson
Journal:  Eukaryot Cell       Date:  2009-07-24

Review 9.  Molecular analysis of early host cell infection by Trypanosoma cruzi.

Authors:  Fernando Villalta; M Nia Madison; Yuliya Y Kleshchenko; Pius N Nde; Maria F Lima
Journal:  Front Biosci       Date:  2008-05-01

10.  Lytic anti-alpha-galactosyl antibodies from patients with chronic Chagas' disease recognize novel O-linked oligosaccharides on mucin-like glycosyl-phosphatidylinositol-anchored glycoproteins of Trypanosoma cruzi.

Authors:  I C Almeida; M A Ferguson; S Schenkman; L R Travassos
Journal:  Biochem J       Date:  1994-12-15       Impact factor: 3.857
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