PURPOSE: We tested the hypothesis that weight for height, a simple index of nutritional status, is related to prognosis in childhood acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS: The study population was composed of 78 children with ALL tested at one U.K. center on the same protocol (UKALL-X). Outcome measures were relapse/no relapse and time to first relapse. Influence of weight for height, expressed as standard deviation scores, was tested using survival analysis in a retrospective design. RESULTS: The weight-for-height standard deviation score had a significant influence on time until first relapse (log ranks test, p = 0.012), with the highest risk of early relapse in children at the lower end of the weight-for-height distribution. CONCLUSIONS: The results suggest that weight for height does have an influence on outcome in ALL, but the mechanism is unclear and the finding requires confirmation by larger scale prospective studies.
PURPOSE: We tested the hypothesis that weight for height, a simple index of nutritional status, is related to prognosis in childhood acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS: The study population was composed of 78 children with ALL tested at one U.K. center on the same protocol (UKALL-X). Outcome measures were relapse/no relapse and time to first relapse. Influence of weight for height, expressed as standard deviation scores, was tested using survival analysis in a retrospective design. RESULTS: The weight-for-height standard deviation score had a significant influence on time until first relapse (log ranks test, p = 0.012), with the highest risk of early relapse in children at the lower end of the weight-for-height distribution. CONCLUSIONS: The results suggest that weight for height does have an influence on outcome in ALL, but the mechanism is unclear and the finding requires confirmation by larger scale prospective studies.
Authors: Etan Orgel; Richard Sposto; Jemily Malvar; Nita L Seibel; Elena Ladas; Paul S Gaynon; David R Freyer Journal: J Clin Oncol Date: 2014-03-31 Impact factor: 44.544
Authors: Marissa A H den Hoed; Saskia M F Pluijm; Hester A de Groot-Kruseman; Mariël L te Winkel; Martha Fiocco; Erica L T van den Akker; Peter Hoogerbrugge; Henk van den Berg; Jan A Leeuw; Marrie C A Bruin; Dorine Bresters; Anjo J P Veerman; Rob Pieters; Marry M van den Heuvel-Eibrink Journal: Haematologica Date: 2014-10-10 Impact factor: 9.941
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