Literature DB >> 8035912

Omega-conotoxin MVIIC reversibly inhibits a human N-type calcium channel and calcium influx into chick synaptosomes.

C J Grantham1, D Bowman, C P Bath, D C Bell, D Bleakman.   

Abstract

We have investigated the effects of omega-CmTX MVIIC on the recombinant alpha 1B-mediated calcium channel expressed in HEK 293 cells and on the predominantly N-type calcium channel in chick synaptosomes. omega-CmTX MVIIC potently and reversibly inhibited the calcium current through alpha 1B-mediated calcium channels and inhibited KCl-evoked increases in [Ca2+]i in chick synaptosomes in a concentration-dependent manner.

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Year:  1994        PMID： 8035912     DOI： 10.1016/0028-3908(94)90017-5

Source DB:  PubMed          Journal:  Neuropharmacology        ISSN： 0028-3908            Impact factor:   5.250


  13 in total

1.  R-Type Ca2+ channels are coupled to the rapid component of secretion in mouse adrenal slice chromaffin cells.

Authors:  A Albillos; E Neher; T Moser
Journal:  J Neurosci       Date:  2000-11-15       Impact factor: 6.167

2.  Modulation of potassium-evoked [3H]dopamine release from rat striatal slices by voltage-activated calcium channel ligands: effects of omega-conotoxin-MVIIC.

Authors:  D Dobrev; K Andreas
Journal:  Neurochem Res       Date:  1997-09       Impact factor: 3.996

3.  Multiple subtypes of voltage-gated calcium channel mediate transmitter release from parasympathetic neurons in the mouse bladder.

Authors:  S A Waterman
Journal:  J Neurosci       Date:  1996-07-01       Impact factor: 6.167

4.  A novel tool for the investigation of glutamate release from rat cerebrocortical synaptosomes: the toxin Tx3-3 from the venom of the spider Phoneutria nigriventer.

Authors:  M A Prado; C Guatimosim; M V Gomez; C R Diniz; M N Cordeiro; M A Romano-Silva
Journal:  Biochem J       Date:  1996-02-15       Impact factor: 3.857

5.  Slowed N-type calcium channel (CaV2.2) deactivation by the cyclin-dependent kinase inhibitor roscovitine.

Authors:  Zafir Buraei; Mircea Anghelescu; Keith S Elmslie
Journal:  Biophys J       Date:  2005-06-10       Impact factor: 4.033

6.  Prolonged attenuation of amygdala-kindled seizure measures in rats by convection-enhanced delivery of the N-type calcium channel antagonists omega-conotoxin GVIA and omega-conotoxin MVIIA.

Authors:  Maciej Gasior; Natalie A White; Michael A Rogawski
Journal:  J Pharmacol Exp Ther       Date:  2007-08-23       Impact factor: 4.030

7.  Voltage-dependent calcium channels are involved in neurogenic dural vasodilatation via a presynaptic transmitter release mechanism.

Authors:  S Akerman; D J Williamson; P J Goadsby
Journal:  Br J Pharmacol       Date:  2003-08-26       Impact factor: 8.739

Review 8.  Molecular pharmacology of high voltage-activated calcium channels.

Authors:  Clinton J Doering; Gerald W Zamponi
Journal:  J Bioenerg Biomembr       Date:  2003-12       Impact factor: 2.945

9.  Calcium channel subtypes for the sympathetic and parasympathetic nerves of guinea-pig atria.

Authors:  S J Hong; C C Chang
Journal:  Br J Pharmacol       Date:  1995-09       Impact factor: 8.739

10.  Characterization of the type of calcium channel primarily regulating GABA exocytosis from brain nerve endings.

Authors:  M Sitges; L M Chiu
Journal:  Neurochem Res       Date:  1995-09       Impact factor: 3.996
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