Literature DB >> 8035530

Specificity and sequence requirements for interactions between various retroviral Gag proteins.

E K Franke1, H E Yuan, K L Bossolt, S P Goff, J Luban.   

Abstract

We previously established a genetic assay for retroviral Gag polyprotein multimerization (J. Luban, K. B. Alin, K. L. Bossolt, T. Humaran, and S. P. Goff, J. Virol. 66:5157-5160, 1992). Here we use this assay to demonstrate homomeric interactions between Gag polyproteins encoded by six different retroviruses. Of the Gag polyproteins tested, only those encoded by closely related retroviruses formed heteromultimers. To determine the primary sequence requirements for human immunodeficiency virus type 1 Gag polyprotein multimerization, we studied the effects on multimerization of deletion and linker insertion mutations. Sequences necessary for this process were located between the C-terminal one-third of the capsid domain and the C terminus of the nucleocapsid domain.

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Year:  1994        PMID： 8035530      PMCID： PMC236479     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  52 in total

1.  Mutational inactivation of an inhibitory sequence in human immunodeficiency virus type 1 results in Rev-independent gag expression.

Authors:  S Schwartz; M Campbell; G Nasioulas; J Harrison; B K Felber; G N Pavlakis
Journal:  J Virol       Date:  1992-12       Impact factor: 5.103

2.  Mutations in the N-terminal region of human immunodeficiency virus type 1 matrix protein block intracellular transport of the Gag precursor.

Authors:  X Yuan; X Yu; T H Lee; M Essex
Journal:  J Virol       Date:  1993-11       Impact factor: 5.103

3.  Identification of a region in the Pr55gag-polyprotein essential for HIV-1 particle formation.

Authors:  A von Poblotzki; R Wagner; M Niedrig; G Wanner; H Wolf; S Modrow
Journal:  Virology       Date:  1993-04       Impact factor: 3.616

4.  Genetic analysis of homomeric interactions of human immunodeficiency virus type 1 integrase using the yeast two-hybrid system.

Authors:  G V Kalpana; S P Goff
Journal:  Proc Natl Acad Sci U S A       Date:  1993-11-15       Impact factor: 11.205

5.  Avian retroviral RNA encapsidation: reexamination of functional 5' RNA sequences and the role of nucleocapsid Cys-His motifs.

Authors:  R Aronoff; A M Hajjar; M L Linial
Journal:  J Virol       Date:  1993-01       Impact factor: 5.103

6.  Assembly of the matrix protein of simian immunodeficiency virus into virus-like particles.

Authors:  S A González; J L Affranchino; H R Gelderblom; A Burny
Journal:  Virology       Date:  1993-06       Impact factor: 3.616

7.  Effect of linker insertion mutations in the human immunodeficiency virus type 1 gag gene on activation of viral protease expressed in bacteria.

Authors:  J Luban; C Lee; S P Goff
Journal:  J Virol       Date:  1993-06       Impact factor: 5.103

8.  Assembly, processing, and infectivity of human immunodeficiency virus type 1 gag mutants.

Authors:  C T Wang; E Barklis
Journal:  J Virol       Date:  1993-07       Impact factor: 5.103

9.  Characterization of a small (25-kilodalton) derivative of the Rous sarcoma virus Gag protein competent for particle release.

Authors:  R A Weldon; J W Wills
Journal:  J Virol       Date:  1993-09       Impact factor: 5.103

10.  Assembly-defective point mutants of the human immunodeficiency virus type 1 Gag precursor phenotypically expressed in recombinant baculovirus-infected cells.

Authors:  S S Hong; P Boulanger
Journal:  J Virol       Date:  1993-05       Impact factor: 5.103
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  55 in total

1.  Identification of residues of the Moloney murine leukemia virus nucleocapsid critical for viral DNA synthesis in vivo.

Authors:  J Gonsky; E Bacharach; S P Goff
Journal:  J Virol       Date:  2001-03       Impact factor: 5.103

2.  The dimer interfaces of protease and extra-protease domains influence the activation of protease and the specificity of GagPol cleavage.

Authors:  Steven C Pettit; Sergei Gulnik; Lori Everitt; Andrew H Kaplan
Journal:  J Virol       Date:  2003-01       Impact factor: 5.103

3.  Entropic switch regulates myristate exposure in the HIV-1 matrix protein.

Authors:  Chun Tang; Erin Loeliger; Paz Luncsford; Isaac Kinde; Dorothy Beckett; Michael F Summers
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-29       Impact factor: 11.205

4.  Nucleocapsid-RNA interactions are essential to structural stability but not to assembly of retroviruses.

Authors:  Shainn-Wei Wang; Kristin Noonan; Anna Aldovini
Journal:  J Virol       Date:  2004-01       Impact factor: 5.103

5.  Intracellular targeting of Gag proteins of the Drosophila telomeric retrotransposons.

Authors:  S Rashkova; A Athanasiadis; M-L Pardue
Journal:  J Virol       Date:  2003-06       Impact factor: 5.103

6.  Binding of calmodulin to the HIV-1 matrix protein triggers myristate exposure.

Authors:  Ruba H Ghanam; Timothy F Fernandez; Emily L Fledderman; Jamil S Saad
Journal:  J Biol Chem       Date:  2010-10-18       Impact factor: 5.157

7.  A LINE-like transposable element in Drosophila, the I factor, encodes a protein with properties similar to those of retroviral nucleocapsids.

Authors:  A Dawson; E Hartswood; T Paterson; D J Finnegan
Journal:  EMBO J       Date:  1997-07-16       Impact factor: 11.598

8.  RNA dimerization defect in a Rous sarcoma virus matrix mutant.

Authors:  L J Parent; T M Cairns; J A Albert; C B Wilson; J W Wills; R C Craven
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

9.  Basic residues in human immunodeficiency virus type 1 nucleocapsid promote virion assembly via interaction with RNA.

Authors:  A Cimarelli; S Sandin; S Höglund; J Luban
Journal:  J Virol       Date:  2000-04       Impact factor: 5.103

10.  Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B.

Authors:  F Re; D Braaten; E K Franke; J Luban
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103
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