Literature DB >> 8034566

Transition state analysis and inhibitor design for enzymatic reactions.

V L Schramm1, B A Horenstein, P C Kline.   

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Year:  1994        PMID： 8034566

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


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  11 in total

1.  Hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi as a target for structure-based inhibitor design: crystallization and inhibition studies with purine analogs.

Authors:  A E Eakin; A Guerra; P J Focia; J Torres-Martinez; S P Craig
Journal:  Antimicrob Agents Chemother       Date:  1997-08       Impact factor: 5.191

2.  A glycosidase antibody elicited against a chair-like transition state analog by in vitro immunization.

Authors:  J Yu; S Y Choi; K D Moon; H H Chung; H J Youn; S Jeong; H Park; P G Schultz
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-17       Impact factor: 11.205

3.  DNA bending and a flip-out mechanism for base excision by the helix-hairpin-helix DNA glycosylase, Escherichia coli AlkA.

Authors:  T Hollis; Y Ichikawa; T Ellenberger
Journal:  EMBO J       Date:  2000-02-15       Impact factor: 11.598

4.  A complex of methylthioadenosine/S-adenosylhomocysteine nucleosidase, transition state analogue, and nucleophilic water identified by mass spectrometry.

Authors:  Shanzhi Wang; Jihyeon Lim; Keisha Thomas; Funing Yan; Ruth H Angeletti; Vern L Schramm
Journal:  J Am Chem Soc       Date:  2012-01-12       Impact factor: 15.419

5.  Synthesis of bi-substrate state mimics of dihydropteroate synthase as potential inhibitors and molecular probes.

Authors:  Jianjun Qi; Kristopher G Virga; Sourav Das; Ying Zhao; Mi-Kyung Yun; Stephen W White; Richard E Lee
Journal:  Bioorg Med Chem       Date:  2010-12-15       Impact factor: 3.641

6.  Kinetic isotope effects reveal early transition state of protein lysine methyltransferase SET8.

Authors:  Joshua A Linscott; Kanishk Kapilashrami; Zhen Wang; Chamara Senevirathne; Ian R Bothwell; Gil Blum; Minkui Luo
Journal:  Proc Natl Acad Sci U S A       Date:  2016-12-09       Impact factor: 11.205

7.  Transition state structures and the roles of catalytic residues in GAP-facilitated GTPase of Ras as elucidated by (18)O kinetic isotope effects.

Authors:  Xinlin Du; Stephen R Sprang
Journal:  Biochemistry       Date:  2009-06-02       Impact factor: 3.162

8.  Structure-activity study of new inhibitors of human betaine-homocysteine S-methyltransferase.

Authors:  Václav Vanek; Milos Budesínský; Petra Kabeleová; Miloslav Sanda; Milan Kozísek; Ivona Hanclová; Jana Mládková; Jirí Brynda; Ivan Rosenberg; Markos Koutmos; Timothy A Garrow; Jirí Jirácek
Journal:  J Med Chem       Date:  2009-06-25       Impact factor: 7.446

Review 9.  Enzymatic Transition States and Drug Design.

Authors:  Vern L Schramm
Journal:  Chem Rev       Date:  2018-10-18       Impact factor: 60.622

10.  Temperature-Dependent Kinetic Isotope Effects in R67 Dihydrofolate Reductase from Path-Integral Simulations.

Authors:  Anil R Mhashal; Dan Thomas Major
Journal:  J Phys Chem B       Date:  2021-02-01       Impact factor: 2.991
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