RATIONALE AND OBJECTIVES: Although many optical approaches have been investigated to diagnose breast cancers, optical parameters have never been standardized in phantom experiments; thus, the detectabilities in the various approaches could not be compared. The authors measured optical properties of the breast quantitatively using time-resolved reflectance spectroscopy to optimize the optical condition of the phantom. METHODS: A time-correlated single-photon counting method was used to obtain time-response curves of a phantom and human breasts. The optical parameters were analyzed by fitting the curves to the diffusion equation. RESULTS: The parameters could be quantified within approximately 10% error in the finite breast phantom. In vivo preliminary results showed significant individual differences. CONCLUSIONS: The authors were able to measure the optical parameters quantitatively using time-resolved spectroscopy. This optical information will contribute to the investigation of photon migration in the breast.
RATIONALE AND OBJECTIVES: Although many optical approaches have been investigated to diagnose breast cancers, optical parameters have never been standardized in phantom experiments; thus, the detectabilities in the various approaches could not be compared. The authors measured optical properties of the breast quantitatively using time-resolved reflectance spectroscopy to optimize the optical condition of the phantom. METHODS: A time-correlated single-photon counting method was used to obtain time-response curves of a phantom and human breasts. The optical parameters were analyzed by fitting the curves to the diffusion equation. RESULTS: The parameters could be quantified within approximately 10% error in the finite breast phantom. In vivo preliminary results showed significant individual differences. CONCLUSIONS: The authors were able to measure the optical parameters quantitatively using time-resolved spectroscopy. This optical information will contribute to the investigation of photon migration in the breast.
Authors: N Shah; A Cerussi; C Eker; J Espinoza; J Butler; J Fishkin; R Hornung; B Tromberg Journal: Proc Natl Acad Sci U S A Date: 2001-04-03 Impact factor: 11.205