Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A novel mosaic Bantu/Benin/Bantu beta s haplotype found in several African populations.

Literature DB >> 8034287

A novel mosaic Bantu/Benin/Bantu beta s haplotype found in several African populations.

I Gonçalves¹, J Gonçalves, B Périchon, L Osório-Almeida, R Krishnamoorthy, J Lavinha.

Abstract

In a survey of the chromosomal backgrounds associated with the sickle cell gene in Portuguese-speaking populations from Europe and Africa, a discordance between the classical haplotype and the predicted allele at the RsaI polymorphism 5' to the beta globin gene was observed in four patients. Extensive typing of the corresponding beta s chromosomes at simple polymorphic repeat motifs revealed a novel "extended" haplotype that appeared to be a mosaic of (1) a Bantu-type DNase I hypersensitive site 2 within the beta globin gene cluster locus control region, (2) a Benin 5' subhaplotype, and (3) a Bantu 3' subhaplotype. We propose two alternative schedules for the generation of yet another chromosomal background of the sickle cell gene.

Entities: Disease Gene Species

Mesh：

Substances：
DNA Primers
Globins

Year: 1994 PMID： 8034287 DOI： 10.1007/bf02272853

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

12 in total

1. A novel sickle cell mutation of yet another origin in Africa: the Cameroon type.

Authors: C Lapouméroulie; O Dunda; R Ducrocq; G Trabuchet; M Mony-Lobé; J M Bodo; P Carnevale; D Labie; J Elion; R Krishnamoorthy
Journal: Hum Genet Date: 1992-05 Impact factor: 4.132

2. Nucleotide sequence evidence of the unicentric origin of the beta C mutation in Africa.

Authors: G Trabuchet; J Elion; O Dunda; C Lapouméroulie; R Ducrocq; S Nadifi; I Zohoun; A Chaventre; P Carnevale; R L Nagel
Journal: Hum Genet Date: 1991-09 Impact factor: 4.132

3. The hematologic characteristics of sickle cell anemia bearing the Bantu haplotype: the relationship between G gamma and HbF level.

Authors: R L Nagel; S K Rao; O Dunda-Belkhodja; M M Connolly; M E Fabry; A Georges; R Krishnamoorthy; D Labie
Journal: Blood Date: 1987-04 Impact factor: 22.113

4. A simple salting out procedure for extracting DNA from human nucleated cells.

Authors: S A Miller; D D Dykes; H F Polesky
Journal: Nucleic Acids Res Date: 1988-02-11 Impact factor: 16.971

5. Geographical survey of beta S-globin gene haplotypes: evidence for an independent Asian origin of the sickle-cell mutation.

Authors: A E Kulozik; J S Wainscoat; G R Serjeant; B C Kar; B Al-Awamy; G J Essan; A G Falusi; S K Haque; A M Hilali; S Kate
Journal: Am J Hum Genet Date: 1986-08 Impact factor: 11.025

Review 6. DNA polymorphism and molecular pathology of the human globin gene clusters.

Authors: S E Antonarakis; H H Kazazian; S H Orkin
Journal: Hum Genet Date: 1985 Impact factor: 4.132

7. Linkage of beta-thalassaemia mutations and beta-globin gene polymorphisms with DNA polymorphisms in human beta-globin gene cluster.

Authors: S H Orkin; H H Kazazian; S E Antonarakis; S C Goff; C D Boehm; J P Sexton; P G Waber; P J Giardina
Journal: Nature Date: 1982-04-15 Impact factor: 49.962

A novel mosaic Bantu/Benin/Bantu beta s haplotype found in several African populations.

1. A novel sickle cell mutation of yet another origin in Africa: the Cameroon type.

2. Nucleotide sequence evidence of the unicentric origin of the beta C mutation in Africa.

3. The hematologic characteristics of sickle cell anemia bearing the Bantu haplotype: the relationship between G gamma and HbF level.

4. A simple salting out procedure for extracting DNA from human nucleated cells.

5. Geographical survey of beta S-globin gene haplotypes: evidence for an independent Asian origin of the sickle-cell mutation.

Review 6. DNA polymorphism and molecular pathology of the human globin gene clusters.

7. Linkage of beta-thalassaemia mutations and beta-globin gene polymorphisms with DNA polymorphisms in human beta-globin gene cluster.

8. Evidence for the multicentric origin of the sickle cell hemoglobin gene in Africa.

9. Origin of the beta S-globin gene in blacks: the contribution of recurrent mutation or gene conversion or both.

10. Inter-ethnic polymorphism of the beta-globin gene locus control region (LCR) in sickle-cell anemia patients.

1. High level of heterozygous haplotype of hemoglobin in Abidjan population with mild malaria.