| Literature DB >> 8034198 |
S L Payão1, M Smith, M H Kormann-Bortolotto, J Toniolo.
Abstract
The Ag-stained nucleolus organizer regions and the satellite association (SA) were studied in peripheral lymphocyte cultures derived from 10 patients with Alzheimer's disease (AD), 10 elderly controls and 10 young controls. Our results showed a significant lower frequency of Ag staining and SA in relation to the chromosome pair 21 in the AD patient group when compared with the elderly and young control groups. These results point to a reduction in the activity of ribosomal genes in the AD patient group.Entities:
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Year: 1994 PMID： 8034198 DOI： 10.1159/000213569
Source DB: PubMed Journal: Gerontology ISSN： 0304-324X Impact factor: 5.140