Literature DB >> 8034048

Cloning a novel human brain inward rectifier potassium channel and its functional expression in Xenopus oocytes.

W Tang1, X C Yang.   

Abstract

We have cloned a novel inward rectifier K+ channel (hIRK2) from a human frontal cortex cDNA library. The amino acid sequence of hIRK2 shares 60% and 40% identity with the mouse IRK1 and the rat ROMK1 channels, respectively. Xenopus oocytes injected with hIRK2 cRNA showed an inwardly rectifying K+ current that had a prominent 'N-shape' I-V curve and was blocked by extracellular Ba2+. The hIRK2 channel has two unique features: (a) an 18 amino acid insertion between the first transmembrane region and the pore, and (b) restricted mRNA distribution found only in human brain and heart.

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Year:  1994        PMID： 8034048     DOI： 10.1016/0014-5793(94)00612-1

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

1.  Effects of intra- and extracellular acidifications on single channel Kir2.3 currents.

Authors:  G Zhu; S Chanchevalap; N Cui; C Jiang
Journal:  J Physiol       Date:  1999-05-01       Impact factor: 5.182

2.  Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome.

Authors:  Regina Preisig-Müller; Günter Schlichthörl; Tobias Goerge; Steffen Heinen; Andrea Brüggemann; Sindhu Rajan; Christian Derst; Rüdiger W Veh; Jürgen Daut
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-28       Impact factor: 11.205

3.  Regulation of a family of inwardly rectifying potassium channels (Kir2) by the m1 muscarinic receptor and the small GTPase Rho.

Authors:  Todd M Rossignol; S V Penelope Jones
Journal:  Pflugers Arch       Date:  2005-11-19       Impact factor: 3.657

4.  IRK(1-3) and GIRK(1-4) inwardly rectifying K+ channel mRNAs are differentially expressed in the adult rat brain.

Authors:  C Karschin; E Dissmann; W Stühmer; A Karschin
Journal:  J Neurosci       Date:  1996-06-01       Impact factor: 6.167

5.  Kir2.4 and Kir2.1 K(+) channel subunits co-assemble: a potential new contributor to inward rectifier current heterogeneity.

Authors:  Gernot Schram; Peter Melnyk; Marc Pourrier; Zhiguo Wang; Stanley Nattel
Journal:  J Physiol       Date:  2002-10-15       Impact factor: 5.182

6.  Effects of divalent cations on the E-4031-sensitive repolarization current, I(Kr), in rabbit ventricular myocytes.

Authors:  T Paquette; J R Clay; A Ogbaghebriel; A Shrier
Journal:  Biophys J       Date:  1998-03       Impact factor: 4.033

7.  Comparison of cloned Kir2 channels with native inward rectifier K+ channels from guinea-pig cardiomyocytes.

Authors:  G X Liu; C Derst; G Schlichthörl; S Heinen; G Seebohm; A Brüggemann; W Kummer; R W Veh; J Daut; R Preisig-Müller
Journal:  J Physiol       Date:  2001-04-01       Impact factor: 5.182

8.  Functional expression of a vertebrate inwardly rectifying K+ channel in yeast.

Authors:  W Tang; A Ruknudin; W P Yang; S Y Shaw; A Knickerbocker; S Kurtz
Journal:  Mol Biol Cell       Date:  1995-09       Impact factor: 4.138

9.  Physiological and molecular characterization of an IRK-type inward rectifier K+ channel in a tumour mast cell line.

Authors:  E Wischmeyer; K U Lentes; A Karschin
Journal:  Pflugers Arch       Date:  1995-04       Impact factor: 3.657
  9 in total

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