Literature DB >> 8034036

A new UV-filter compound in human lenses.

R J Truscott1, A M Wood, J A Carver, M M Sheil, G M Stutchbury, J Zhu, G W Kilby.   

Abstract

A new UV-filter compound, 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-glucoside, has been identified in human lenses. The structure suggests that it is derived biosynthetically from tryptophan. Quantification studies on the new compound show that it is the second-most abundant UV-filter compound in the lens with an absorption and fluorescence spectrum similar to that of 3-hydroxykynurenine glucoside.

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Year:  1994        PMID: 8034036     DOI: 10.1016/0014-5793(94)00601-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN: 0014-5793            Impact factor:   4.124


  8 in total

1.  A study of kynurenine fragmentation using electrospray tandem mass spectrometry.

Authors:  S Vazquez; R J Truscott; R A O'Hair; A Weimann; M M Sheil
Journal:  J Am Soc Mass Spectrom       Date:  2001-07       Impact factor: 3.109

2.  Kynurenine inhibits fibroblast growth factor 2-mediated expression of crystallins and MIP26 in lens epithelial cells.

Authors:  Maneesh Mailankot; Scott Howell; Ram H Nagaraj
Journal:  Biochim Biophys Acta       Date:  2010-05-15

Review 3.  The nocturnal bottleneck and the evolution of activity patterns in mammals.

Authors:  Menno P Gerkema; Wayne I L Davies; Russell G Foster; Michael Menaker; Roelof A Hut
Journal:  Proc Biol Sci       Date:  2013-07-03       Impact factor: 5.349

4.  The effect of single and repeated UVB radiation on rabbit lens.

Authors:  Miroslav Fris; Jitka Cejková; Anna Midelfart
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2008-01-12       Impact factor: 3.117

5.  Anti-UVC irradiation and metal chelation properties of 6-benzoyl-5,7-dihydroxy-4-phenyl-chromen-2-one: an implications for anti-cataract agent.

Authors:  Jiahn-Haur Liao; Tzu-Hua Wu; Feng-Lin Hsu; Yi-Shiang Huang; Po-Hung Chiang; Zih-You Huang; Chi-Hsien Huang; Shih-Hsiung Wu; Mei-Hsiang Lin
Journal:  Int J Mol Sci       Date:  2011-10-21       Impact factor: 5.923

6.  Tryptophan and Non-Tryptophan Fluorescence of the Eye Lens Proteins Provides Diagnostics of Cataract at the Molecular Level.

Authors:  Anna Gakamsky; Rory R Duncan; Nicola M Howarth; Baljean Dhillon; Kim K Buttenschön; Daniel J Daly; Dmitry Gakamsky
Journal:  Sci Rep       Date:  2017-01-10       Impact factor: 4.379

7.  Tryptophan and kynurenine levels in lenses of Wistar and accelerated-senescence OXYS rats.

Authors:  Olga A Snytnikova; Lyudmila V Kopylova; Elena I Chernyak; Sergey V Morozov; Nataliya G Kolosova; Yuri P Tsentalovich
Journal:  Mol Vis       Date:  2009-12-16       Impact factor: 2.367

8.  Influence of Lens Fluorescence on Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) Fundus Imaging and Strategies for Its Compensation.

Authors:  Jakob Lauritz Brauer; Rowena Schultz; Matthias Klemm; Martin Hammer
Journal:  Transl Vis Sci Technol       Date:  2020-07-09       Impact factor: 3.283

  8 in total

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