Literature DB >> 8034024

KEKE motifs. Proposed roles in protein-protein association and presentation of peptides by MHC class I receptors.

C Realini1, S W Rogers, M Rechsteiner.   

Abstract

A stretch of 28 'alternating' lysine (K) and glutamate (E) residues is found in an activator of the multicatalytic protease. Such 'KEKE sequences' are also present in subunits of the multicatalytic protease, in subunits of the 26S protease and in a variety of chaperonins. We propose that KEKE regions promote association between protein complexes. Furthermore, they may contribute to the selection of peptides presented on MHC Class I receptors.

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Year:  1994        PMID： 8034024     DOI： 10.1016/0014-5793(94)00569-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  34 in total

1.  Developmentally regulated, alternative splicing of the Rpn10 gene generates multiple forms of 26S proteasomes.

Authors:  H Kawahara; M Kasahara; A Nishiyama; K Ohsumi; T Goto; T Kishimoto; Y Saeki; H Yokosawa; N Shimbara; S Murata; T Chiba; K Suzuki; K Tanaka
Journal:  EMBO J       Date:  2000-08-01       Impact factor: 11.598

2.  Proteasome inactivation upon aging and on oxidation-effect of HSP 90.

Authors:  M Conconi; B Friguet
Journal:  Mol Biol Rep       Date:  1997-03       Impact factor: 2.316

3.  Sequence TTKF ↓ QE defines the site of proteolytic cleavage in Mhp683 protein, a novel glycosaminoglycan and cilium adhesin of Mycoplasma hyopneumoniae.

Authors:  Daniel R Bogema; Nichollas E Scott; Matthew P Padula; Jessica L Tacchi; Benjamin B A Raymond; Cheryl Jenkins; Stuart J Cordwell; F Chris Minion; Mark J Walker; Steven P Djordjevic
Journal:  J Biol Chem       Date:  2011-10-03       Impact factor: 5.157

4.  A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes.

Authors:  Jun Hamazaki; Shun-Ichiro Iemura; Tohru Natsume; Hideki Yashiroda; Keiji Tanaka; Shigeo Murata
Journal:  EMBO J       Date:  2006-09-21       Impact factor: 11.598

5.  The twilight zone between protein order and disorder.

Authors:  A Szilágyi; D Györffy; P Závodszky
Journal:  Biophys J       Date:  2008-04-25       Impact factor: 4.033

6.  Subunit arrangement in the human 20S proteasome.

Authors:  F Kopp; K B Hendil; B Dahlmann; P Kristensen; A Sobek; W Uerkvitz
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-01       Impact factor: 11.205

7.  The ubiquitin-proteasome pathway: the complexity and myriad functions of proteins death.

Authors:  A Ciechanover; A L Schwartz
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-17       Impact factor: 11.205

8.  Identification of an activation region in the proteasome activator REGalpha.

Authors:  Z Zhang; A Clawson; C Realini; C C Jensen; J R Knowlton; C P Hill; M Rechsteiner
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-17       Impact factor: 11.205

9.  Molecular cloning of a RNA binding protein, S1-1.

Authors:  A Inoue; K P Takahashi; M Kimura; T Watanabe; S Morisawa
Journal:  Nucleic Acids Res       Date:  1996-08-01       Impact factor: 16.971

10.  CDNA cloning of p112, the largest regulatory subunit of the human 26s proteasome, and functional analysis of its yeast homologue, sen3p.

Authors:  K Yokota; S Kagawa; Y Shimizu; H Akioka; C Tsurumi; C Noda; M Fujimuro; H Yokosawa; T Fujiwara; E Takahashi; M Ohba; M Yamasaki; G N DeMartino; C A Slaughter; A Toh-e; K Tanaka
Journal:  Mol Biol Cell       Date:  1996-06       Impact factor: 4.138
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