Literature DB >> 8033976

Microdialysis study of ischemia-induced hydroxyl radicals in the canine heart.

A A Timoshin1, O V Tskitishvili, L I Serebryakova, A I Kuzmin, O S Medvedev, E K Ruuge.   

Abstract

A new experimental approach for spin-trapping of oxygen radicals in a selected region of the heart in situ is described. This approach is based on microdialysis, and it permits the detection of oxygen radicals in conditions of local ischemia and restoration of normal blood flow. Increased hydroxyl radical generation in an ischemic area of canine myocardium, as a result of 40 min local occlusion, has been studied.

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Year:  1994        PMID： 8033976     DOI： 10.1007/bf01952872

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  21 in total

1.  In vivo EPR oximetry using two novel probes: fusinite and lithium phthalocyanine.

Authors:  J F Glockner; H M Swartz
Journal:  Adv Exp Med Biol       Date:  1992       Impact factor: 2.622

2.  The cellular-induced decay of DMPO spin adducts of .OH and .O2.

Authors:  A Samuni; A Samuni; H M Swartz
Journal:  Free Radic Biol Med       Date:  1989       Impact factor: 7.376

Review 3.  Measurement of oxygen concentrations in the intact beating heart using electron paramagnetic resonance spectroscopy: a technique for measuring oxygen concentrations in situ.

Authors:  J L Zweier; S Thompson-Gorman; P Kuppusamy
Journal:  J Bioenerg Biomembr       Date:  1991-12       Impact factor: 2.945

Review 4.  Reperfusion injury.

Authors:  J T Flaherty; M L Weisfeldt
Journal:  Free Radic Biol Med       Date:  1988       Impact factor: 7.376

5.  Detection of oxygen-derived free radical generation in the canine postischemic heart during late phase of reperfusion.

Authors:  T Kuzuya; S Hoshida; Y Kim; M Nishida; H Fuji; A Kitabatake; M Tada; T Kamada
Journal:  Circ Res       Date:  1990-04       Impact factor: 17.367

6.  Studies on the effects of antioxidants and inhibitors of radical generation on free radical production in the reperfused rat heart using electron spin resonance spectroscopy.

Authors:  S L Shuter; M J Davies; P B Garlick; D J Hearse; T F Slater
Journal:  Free Radic Res Commun       Date:  1990

7.  Use of 3,3,5,5-tetramethyl-1-pyrroline-1-oxide spin trap for the continuous flow ESR monitoring of hydroxyl radical generation in the ischemic and reperfused myocardium.

Authors:  M Culcasi; S Pietri; P J Cozzone
Journal:  Biochem Biophys Res Commun       Date:  1989-11-15       Impact factor: 3.575

8.  Spin trapping evidence for radical generation by isolated hearts and cultured heart cells.

Authors:  I E Blasig; B Ebert; G Wallukat; H Loewe
Journal:  Free Radic Res Commun       Date:  1989

9.  Functional role of collateral flow in the ischaemic dog heart.

Authors:  J R Koke; N Bittar
Journal:  Cardiovasc Res       Date:  1978-05       Impact factor: 10.787

Review 10.  Molecular oxygen: friend and foe. The role of the oxygen free radical system in the calcium paradox, the oxygen paradox and ischemia/reperfusion injury.

Authors:  M L Hess; N H Manson
Journal:  J Mol Cell Cardiol       Date:  1984-11       Impact factor: 5.000
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  1 in total

1.  Protective effect of dinitrosyl-iron complexes with glutathione in rat myocardial regional ischemia: a microdialysis assay study.

Authors:  A A Timoshin; D Yu Drobotov; O V Tskitishvili; L I Serebryakova; O I Pisarenko; E K Ruuge; A F Vanin
Journal:  Dokl Biochem Biophys       Date:  2010 May-Jun       Impact factor: 0.788
  1 in total

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