| Literature DB >> 8033257 |
M W Coughtrie1, K J Bamforth, S Sharp, A L Jones, E B Borthwick, E V Barker, R C Roberts, R Hume, A Burchell.
Abstract
Sulfation is a major detoxication mechanism for endogenous compounds and xenobiotics performed by a family of sulfotransferase isoenzymes. Understanding the normal cellular functions of these different sulfotransferases and the way in which endogenous and exogenous factors are able to influence their activity and expression will provide us with the information necessary to develop novel therapeutic strategies for conditions where sulfation may be implicated. This concept is discussed and is illustrated by examples including adverse drug reactions, fetal development and cancer.Entities:
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Year: 1994 PMID： 8033257 DOI： 10.1016/0009-2797(94)90067-1
Source DB: PubMed Journal: Chem Biol Interact ISSN： 0009-2797 Impact factor: 5.192