Literature DB >> 8033151

A homozygous deletion in a small cell lung cancer cell line involving a 3p21 region with a marked instability in yeast artificial chromosomes.

K Kok1, A van den Berg, P M Veldhuis, A Y van der Veen, M Franke, E F Schoenmakers, M M Hulsbeek, A H van der Hout, L de Leij, W van de Ven.   

Abstract

All types of lung carcinoma are characterized by a high frequency of loss of sequences from the short arm of chromosome 3, the smallest region of overlap containing D3F15S2 in band p21. Here we characterize a 440-kilobase segment from this region, which we found homozygously deleted in one of our small cell lung cancer-derived cell lines. The homozygous deletion maps between UBE1L and ZnF16, just centromeric to D3F15S2. Yeast artificial chromosomes with inserts originating from the deleted region are very unstable and readily lose parts of their insert.

Entities:  

Mesh：

Year:  1994        PMID： 8033151

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  16 in total

1.  NotI flanking sequences: a tool for gene discovery and verification of the human genome.

Authors:  Alexey S Kutsenko; Rinat Z Gizatullin; Ali N Al-Amin; Fuli Wang; Sergei M Kvasha; Raf M Podowski; Yuri G Matushkin; Anita Gyanchandani; Olga V Muravenko; Viktor G Levitsky; Nikolay A Kolchanov; Alexei I Protopopov; Vladimir I Kashuba; Lev L Kisselev; Wyeth Wasserman; Claes Wahlestedt; Eugene R Zabarovsky
Journal:  Nucleic Acids Res       Date:  2002-07-15       Impact factor: 16.971

2.  Semaphorin SEMA3F localization in malignant human lung and cell lines: A suggested role in cell adhesion and cell migration.

Authors:  E Brambilla; B Constantin; H Drabkin; J Roche
Journal:  Am J Pathol       Date:  2000-03       Impact factor: 4.307

3.  Selective suppression of in vivo tumorigenicity by semaphorin SEMA3F in lung cancer cells.

Authors:  Sophie Kusy; Patrick Nasarre; Daniel Chan; Vincent Potiron; David Meyronet; Robert M Gemmill; Bruno Constantin; Harry A Drabkin; Joëlle Roche
Journal:  Neoplasia       Date:  2005-05       Impact factor: 5.715

4.  High-resolution chromosome 3p allelotyping of breast carcinomas and precursor lesions demonstrates frequent loss of heterozygosity and a discontinuous pattern of allele loss.

Authors:  A Maitra; I I Wistuba; C Washington; A K Virmani; R Ashfaq; S Milchgrub; A F Gazdar; J D Minna
Journal:  Am J Pathol       Date:  2001-07       Impact factor: 4.307

5.  Mapping of a new MAP kinase activated protein kinase gene (3PK) to human chromosome band 3p21.2 and ordering of 3PK and two cosmid markers in the 3p22-p21 tumour-suppressor region by two-colour fluorescence in situ hybridization.

Authors:  A Szeles; S Bajalica-Lagercrantz; A Lindblom; T Lushnikova; V I Kashuba; S Imreh; M Nordenskjöld; G Klein; E R Zabarovsky
Journal:  Chromosome Res       Date:  1996-06       Impact factor: 5.239

6.  Differential screening of a human chromosome 3 library identifies hepatocyte growth factor-like/macrophage-stimulating protein and its receptor in injured lung. Possible implications for neuroendocrine cell survival.

Authors:  C G Willett; D I Smith; V Shridhar; M H Wang; R L Emanuel; K Patidar; S A Graham; F Zhang; V Hatch; D J Sugarbaker; M E Sunday
Journal:  J Clin Invest       Date:  1997-06-15       Impact factor: 14.808

7.  3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region.

Authors:  G Sithanandam; F Latif; F M Duh; R Bernal; U Smola; H Li; I Kuzmin; V Wixler; L Geil; S Shrestha
Journal:  Mol Cell Biol       Date:  1996-03       Impact factor: 4.272

8.  Coincidence of synteny breakpoints with malignancy-related deletions on human chromosome 3.

Authors:  Maria Kost-Alimova; Hajnalka Kiss; Ludmila Fedorova; Ying Yang; Jan P Dumanski; George Klein; Stefan Imreh
Journal:  Proc Natl Acad Sci U S A       Date:  2003-05-08       Impact factor: 11.205

9.  Chromosome 3p loss of heterozygosity and mutation analysis of the FHIT and beta-cat genes in squamous cell carcinoma of the head and neck.

Authors:  M V González; M F Pello; P Ablanedo; C Suárez; V Alvarez; E Coto
Journal:  J Clin Pathol       Date:  1998-07       Impact factor: 3.411

Review 10.  Cyclin D1 and human neoplasia.

Authors:  R Donnellan; R Chetty
Journal:  Mol Pathol       Date:  1998-02
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