Literature DB >> 8032210

mRNA translation: influence of the 5' and 3' untranslated regions.

N Sonenberg1.   

Abstract

Eukaryotic messenger RNA utilization is a tightly controlled process. Control of translation is exerted at several levels, but the predominant step is ribosome binding, which is rate limiting for translation of most mRNAs. There appear to be several alternative modes by which ribosomes bind to the mRNA and initiate translation. Recent data show that both the 5' and 3' untranslated regions of eukaryotic mRNAs play critical roles in mRNA recruitment for translation, and several cis-acting elements have been characterized in detail. In addition, a few trans-acting factors that bind to these elements have been identified. It is possible that the terminal regions of mRNAs interact to enhance translation.

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Year:  1994        PMID： 8032210     DOI： 10.1016/s0959-437x(05)80059-0

Source DB:  PubMed          Journal:  Curr Opin Genet Dev        ISSN： 0959-437X            Impact factor:   5.578


  55 in total

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Authors:  G Pesole; S Liuni; G Grillo; F Licciulli; A Larizza; W Makalowski; C Saccone
Journal:  Nucleic Acids Res       Date:  2000-01-01       Impact factor: 16.971

Review 3.  Translational control of viral gene expression in eukaryotes.

Authors:  M Gale; S L Tan; M G Katze
Journal:  Microbiol Mol Biol Rev       Date:  2000-06       Impact factor: 11.056

Review 4.  Beta1,4-galactosyltransferase and lactose biosynthesis: recruitment of a housekeeping gene from the nonmammalian vertebrate gene pool for a mammary gland specific function.

Authors:  N L Shaper; M Charron; N W Lo; J H Shaper
Journal:  J Mammary Gland Biol Neoplasia       Date:  1998-07       Impact factor: 2.673

5.  Translation is regulated via the 3' untranslated region of alpha-myosin heavy chain mRNA by calcium but not by its localization.

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Journal:  J Muscle Res Cell Motil       Date:  2000       Impact factor: 2.698

6.  Effect of intercistronic length on internal ribosome entry site (IRES) efficiency in bicistronic mRNA.

Authors:  J Attal; M C Theron; C Puissant; L M Houdebine
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7.  The pattern of gene expression in human CD34(+) stem/progenitor cells.

Authors:  G Zhou; J Chen; S Lee; T Clark; J D Rowley; S M Wang
Journal:  Proc Natl Acad Sci U S A       Date:  2001-11-20       Impact factor: 11.205

8.  UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs. Update 2002.

Authors:  Graziano Pesole; Sabino Liuni; Giorgio Grillo; Flavio Licciulli; Flavio Mignone; Carmela Gissi; Cecilia Saccone
Journal:  Nucleic Acids Res       Date:  2002-01-01       Impact factor: 16.971

9.  Regulation of gene expression by internal ribosome entry sites or cryptic promoters: the eIF4G story.

Authors:  Baoguang Han; Jian-Ting Zhang
Journal:  Mol Cell Biol       Date:  2002-11       Impact factor: 4.272

10.  Characterization of the 5'-untranslated region of YB-1 mRNA and autoregulation of translation by YB-1 protein.

Authors:  Takao Fukuda; Megumi Ashizuka; Takanori Nakamura; Kotaro Shibahara; Katsumasa Maeda; Hiroto Izumi; Kimitoshi Kohno; Michihiko Kuwano; Takeshi Uchiumi
Journal:  Nucleic Acids Res       Date:  2004-01-29       Impact factor: 16.971
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