Literature DB >> 8031058

Regulation of herpes simplex virus thymidine kinase in cells treated with a synergistic antiviral combination of alpha interferon and acyclovir.

J L Taylor1, P Tom, J Guy, R M Selvarajan, W J O'Brien.   

Abstract

Alpha interferon (IFN-alpha) and acyclovir (ACV) are synergistic in their anti-herpes simplex virus activities. IFN-alpha treatment reduced the herpes simplex virus thymidine kinase (TK) activity present in cells 6 h postinfection, while steady-state levels of TK mRNA remained at or above the amount in infected, untreated cells. The inhibition of TK production by IFN-alpha treatment appeared to be transient and translational, not transcriptional.

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Year:  1994        PMID： 8031058      PMCID： PMC284554          DOI： 10.1128/AAC.38.4.853

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  24 in total

1.  Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.

Authors:  J A Fyfe; P M Keller; P A Furman; R L Miller; G B Elion
Journal:  J Biol Chem       Date:  1978-12-25       Impact factor: 5.157

2.  Loss of resolution in gel electrophoresis of RNA: a problem associated with the presence of formaldehyde gradients.

Authors:  S S Tsang; X Yin; C Guzzo-Arkuran; V S Jones; A J Davison
Journal:  Biotechniques       Date:  1993-03       Impact factor: 1.993

3.  In vitro and in vivo transcription initiation sites on the TK-encoding BamHI Q fragment of HSV-1 DNA.

Authors:  G S Read; J A Sharp; W C Summers
Journal:  Virology       Date:  1984-10-30       Impact factor: 3.616

4.  Nucleotide sequence of the thymidine kinase gene of herpes simplex virus type 1.

Authors:  M J Wagner; J A Sharp; W C Summers
Journal:  Proc Natl Acad Sci U S A       Date:  1981-03       Impact factor: 11.205

5.  The nucleotide sequence and transcript map of the herpes simplex virus thymidine kinase gene.

Authors:  S L McKnight
Journal:  Nucleic Acids Res       Date:  1980-12-20       Impact factor: 16.971

6.  Transcription of herpes simplex virus genes in vivo: overlap of a late promoter with the 3' end of the early thymidine kinase gene.

Authors:  J A Sharp; M J Wagner; W C Summers
Journal:  J Virol       Date:  1983-01       Impact factor: 5.103

7.  Accumulation of herpes simplex virus type 1 RNAs of different kinetic classes in the cytoplasm of infected cells.

Authors:  E Harris-Hamilton; S L Bachenheimer
Journal:  J Virol       Date:  1985-01       Impact factor: 5.103

8.  Synthesis of herpes simplex virus proteins in interferon-treated human cells.

Authors:  I Gloger; A Panet
Journal:  J Gen Virol       Date:  1984-06       Impact factor: 3.891

9.  Formation of non-infective herpesvirus particles in cultured cells treated with human interferon.

Authors:  A Muñoz; L Carrasco
Journal:  J Gen Virol       Date:  1984-06       Impact factor: 3.891

10.  Acyclovir triphosphate is a suicide inactivator of the herpes simplex virus DNA polymerase.

Authors:  P A Furman; M H St Clair; T Spector
Journal:  J Biol Chem       Date:  1984-08-10       Impact factor: 5.157
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  1 in total

1.  Interleukin-12 exhibits potent antiviral activity in experimental herpesvirus infections.

Authors:  J A Carr; J Rogerson; M J Mulqueen; N A Roberts; R F Booth
Journal:  J Virol       Date:  1997-10       Impact factor: 5.103
  1 in total

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