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Literature DB >> 803103

Role of sialic acid in erythrocyte survival.

Abstract

The role of membrane sialic acid in erythrocyte survival is unclear, although there is evidence for a reduction in sialic acid and surface charge in older erythrocytes. We reduced the surface charge of human, rat, and rabbit erythrocytes by removing sialic acid with neuraminidase. Reduction in sialic acid correlated with decreases in electrophoretic mobility and loss of PAS staining of membrane glycoproteins on polyacrylamide gels. No changes in ATP levels or deformability were found. 51Cr erythrocyte survivals in rats and rabbits showed rapid clearance of desialylated erythrocytes with sequestration by the liver. These results suggest that reduction in erythrocyte sialic acid is a mechanism of erythrocyte destruction and may be important in erythrocyte senescence.

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Year: 1975 PMID： 803103

Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 22.113

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Cited

42 in total

1. Identification of differences between the surface proteins and glycoproteins of normal mouse (Balb/c) and human erythrocytes.

Authors: R J Howard; P M Smith; G F Mitchell
Journal: J Membr Biol Date: 1979-08 Impact factor: 1.843

2. Mechanism of removal of senescent cells by human macrophages in situ.

Authors: M M Kay
Journal: Proc Natl Acad Sci U S A Date: 1975-09 Impact factor: 11.205

3. Identification of a sialoglycopeptide released by self-digestion from human erythrocyte membranes.

Authors: A Brovelli; G Pallavicini; F Sinigaglia; C L Balduini; C Balduini
Journal: Biochem J Date: 1976-08-15 Impact factor: 3.857

4. Liver homing in the rat of 111Indium labelled beef and neuraminidase-treated rat erythrocytes (studies with a gamma camera).

Authors: E Friedrich; R Süss; D Hock; G Uhlenbruck; R Kubesch; H Sinn
Journal: Experientia Date: 1977-08-15

5. Murine T Cell Maturation Entails Protection from MBL2, but Complement Proteins Do Not Drive Clearance of Cells That Fail Maturation in the Absence of NKAP.

Authors: Barsha Dash; Paul J Belmonte; Sydney R Fine; Michael J Shapiro; Ji Young Chung; Aaron D Schwab; Shaylene A McCue; Matthew J Rajcula; Virginia Smith Shapiro
Journal: J Immunol Date: 2019-06-07 Impact factor: 5.422

Role of sialic acid in erythrocyte survival.

1. Identification of differences between the surface proteins and glycoproteins of normal mouse (Balb/c) and human erythrocytes.

2. Mechanism of removal of senescent cells by human macrophages in situ.

3. Identification of a sialoglycopeptide released by self-digestion from human erythrocyte membranes.

4. Liver homing in the rat of 111Indium labelled beef and neuraminidase-treated rat erythrocytes (studies with a gamma camera).

5. Murine T Cell Maturation Entails Protection from MBL2, but Complement Proteins Do Not Drive Clearance of Cells That Fail Maturation in the Absence of NKAP.

6. Vascular endothelium leaves fingerprints on the surface of erythrocytes.

7. The Gardos effect drives erythrocyte senescence and leads to Lu/BCAM and CD44 adhesion molecule activation.

8. Interfacial interactions between natural RBC membranes and synthetic polymeric nanoparticles.

9. Sequestration of neuraminidase-treated erythrocytes. Studies on its topographic, morphologic and immunologic aspects.

10. Surface functionalization of gold nanoparticles with red blood cell membranes.