Literature DB >> 803011

Tay-Sachs disease: high gene frequency in a non-Jewish population.

T E Kelly1, G A Chase, M M Kaback, K Kumor, V A McKusick.   

Abstract

A non-Amish "Pennsylvania Dutch" semi-isolate was found to have a high frequency of Tay-Sachs gene. This high frequency could be ascribed to founder effect and may represent, in microcosm, how this mechanism could have produced the high gene frequency among Ashkenazi Jews.

Entities:  

Mesh：

Year:  1975        PMID： 803011      PMCID： PMC1762873     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  5 in total

1.  THE DISTRIBUTION OF CERTAIN GENES IN THE OLD ORDER AMISH.

Authors:  V A MCKUSICK; J A HOSTETLER; J A EGELAND; R ELDRIDGE
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1964

2.  Founder effect in Tay-Sachs disease.

Authors:  A G Knudson
Journal:  Am J Hum Genet       Date:  1973-01       Impact factor: 11.025

3.  Controversy in human genetics: founder effect in Tay-Sachs disease.

Authors:  G A Chase; V A McKusick
Journal:  Am J Hum Genet       Date:  1972-05       Impact factor: 11.025

Review 4.  Approaches to the control and prevention of Tay-Sachs disease.

Authors:  M M Kaback; R S Zeiger; L W Reynolds; M Sonneborn
Journal:  Prog Med Genet       Date:  1974

5.  Population dynamics of Tay-Sachs disease. I. Reproductive fitness and selection.

Authors:  N C Myrianthopoulos; S M Aronson
Journal:  Am J Hum Genet       Date:  1966-07       Impact factor: 11.025
  5 in total
  5 in total

1.  Bloom's syndrome. VI. The disorder in Israel and an estimation of the gene frequency in the Ashkenazim.

Authors:  J German; D Bloom; E Passarge; K Fried; R M Goodman; I Katzenellenbogen; Z Laron; C Legum; S Levin
Journal:  Am J Hum Genet       Date:  1977-11       Impact factor: 11.025

2.  Novel mutations and DNA-based screening in non-Jewish carriers of Tay-Sachs disease.

Authors:  B R Akerman; M R Natowicz; M M Kaback; M Loyer; E Campeau; R A Gravel
Journal:  Am J Hum Genet       Date:  1997-05       Impact factor: 11.025

3.  A pseudodeficiency allele common in non-Jewish Tay-Sachs carriers: implications for carrier screening.

Authors:  B L Triggs-Raine; E H Mules; M M Kaback; J S Lim-Steele; C E Dowling; B R Akerman; M R Natowicz; E E Grebner; R Navon; J P Welch
Journal:  Am J Hum Genet       Date:  1992-10       Impact factor: 11.025

4.  Elevated frequency of Tay-Sachs disease among Ashkenazic Jews unlikely by genetic drift alone.

Authors:  A Chakravarti; R Chakraborty
Journal:  Am J Hum Genet       Date:  1978-05       Impact factor: 11.025

5.  Identification and rapid detection of three Tay-Sachs mutations in the Moroccan Jewish population.

Authors:  L Drucker; R L Proia; R Navon
Journal:  Am J Hum Genet       Date:  1992-08       Impact factor: 11.025
  5 in total

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