Literature DB >> 8028389

Polymorphonuclear leukocyte-generated oxygen metabolites decrease beat frequency of human respiratory cilia.

A Kantar1, N Oggiano, P L Giorgi, P C Braga, R Fiorini.   

Abstract

We investigated the effect of polymorphonuclear leukocyte (PMN)-generated oxygen metabolites on the ciliary beat frequency. PMNs were incubated with human respiratory cilia obtained by nasal brushing. The oxidative metabolism was stimulated by opsonized zymosan, and ciliary beat frequency was evaluated before and after activation of PMNs. Ciliary beat frequency was studied using video microscopy. Our results demonstrate a significant decrease in ciliary beat frequency after activation of PMNs. This effect was reduced by catalase. These data suggest that the PMN-generated oxygen metabolites, particularly H2O2, decrease beat frequency of human respiratory cilia.

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Year:  1994        PMID： 8028389     DOI： 10.1007/bf00164438

Source DB:  PubMed          Journal:  Lung        ISSN： 0341-2040            Impact factor:   2.584


  34 in total

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  10 in total

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