Literature DB >> 8027743

Platinum (II) complexes of benzoic- and 3-methoxybenzoic acid hydrazides. Synthesis, characterization, and cytotoxic effect.

N Dodoff1, K Grancharov, R Gugova, N Spassovska.   

Abstract

The complexes [Pt(bah)2X2], [Pt(NH3)(bah)Cl2].0.5H2O, [Pt(mbah)2X2], and [Pt(NH3)(mbah)Cl2] (bah = benzoic acid hydrazide, mbah = 3-methoxybenzoic acid hydrazide; X = Cl, Br, I) have been prepared and characterized by elemental analysis, electric conductivity, IR, 1H NMR, and electronic spectra. A cis-square planar structure with hydrazide ligands coordinated via the NH2-groups has been proposed for these complexes. The complexes have shown a growth-inhibitory effect against Friend leukemia cells in culture comparable to that of the antitumor drug cisplatin.

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Year:  1994        PMID： 8027743     DOI： 10.1016/0162-0134(94)80015-4

Source DB:  PubMed          Journal:  J Inorg Biochem        ISSN： 0162-0134            Impact factor:   4.155


  2 in total

1.  Synthesis, Structural Characterization, and Antitumor Activity of a Ca(II) Coordination Polymer Based on 1,6-Naphthalenedisulfonate and 4,4'-Bipyridyl.

Authors:  Xishi Tai; Wenhua Zhao
Journal:  Materials (Basel)       Date:  2013-08-16       Impact factor: 3.623

2.  A selective CuII complex with 4-fluorophenoxyacetic acid hydrazide and phenanthroline displays DNA-cleaving and pro-apoptotic properties in cancer cells.

Authors:  Pedro Henrique Alves Machado; Drielly Aparecida Paixão; Ricardo Campos Lino; Tiago Rodrigues de Souza; Nayara Júnia de Souza Bontempo; Luana Munique Sousa; Fernanda Van Petten de Vasconcelos Azevedo; Priscila Capelari Orsolin; Paula Marynella Alves Pereira Lima; Isabella Castro Martins; Joyce Ferreira da Costa Guerra; Samuel Cota Teixeira; Thaise Gonçalves Araújo; Luiz Ricardo Goulart; Sandra Morelli; Wendell Guerra; Robson José de Oliveira Júnior
Journal:  Sci Rep       Date:  2021-12-27       Impact factor: 4.379
  2 in total

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