Literature DB >> 8027072

Expression of a functional human type I interferon receptor in hamster cells: application of functional yeast artificial chromosome (YAC) screening.

J Soh1, T M Mariano, J K Lim, L Izotova, O Mirochnitchenko, B Schwartz, J A Langer, S Pestka.   

Abstract

The previously cloned human interferon alpha/beta (Hu-IFN-alpha/beta; Type I interferon) receptor cDNA appears to be only one component of a receptor complex since expression of the cDNA in mouse cells confers sensitivity only to Hu-IFN-alpha B2, but a monoclonal antibody against this cloned receptor subunit inhibits biological activities of Hu-IFN-alpha A, Hu-IFN-alpha B2, Hu-IFN-omega, and Hu-IFN-beta. Here we report that a yeast artificial chromosome (YAC) containing a segment of human chromosome 21 introduced into Chinese hamster ovary (CHO) cells confers upon these cells a greatly enhanced response to Hu-IFN-alpha A and Hu-IFN-alpha B2 as well as an increased response to Hu-IFN-omega, Hu-IFN-alpha A/D(Bgl), andd Hu-IFN-beta. These responses were measured by induction of class I MHC antigens and by protection against encephalomyocarditis virus and vesicular stomatitis virus. Furthermore, these cells exhibit specific high affinity binding of Hu-IFN-alpha A and Hu-IFN-alpha B2, Hu-IFN-beta, and Hu-IFN-omega. The results indicate that all the genes necessary to reconstitute a biologically active Type I human IFN receptor complex are located within the human DNA insert of this YAC clone.

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Year:  1994        PMID： 8027072

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  7 in total

1.  A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses.

Authors:  S Y Hwang; P J Hertzog; K A Holland; S H Sumarsono; M J Tymms; J A Hamilton; G Whitty; I Bertoncello; I Kola
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-21       Impact factor: 11.205

2.  Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein.

Authors:  H Yan; K Krishnan; A C Greenlund; S Gupta; J T Lim; R D Schreiber; C W Schindler; J J Krolewski
Journal:  EMBO J       Date:  1996-03-01       Impact factor: 11.598

3.  Efficient co-expression of bicistronic proteins in mesenchymal stem cells by development and optimization of a multifunctional plasmid.

Authors:  Christopher D Krause; Lara S Izotova; Gwangwen Ren; Zeng-Rong Yuan; Yufang Shi; Chiann-Chyi Chen; Yacov Ron; Sidney Pestka
Journal:  Stem Cell Res Ther       Date:  2011-03-14       Impact factor: 6.832

4.  Potential mediators of in ovo delivered double stranded (ds) RNA-induced innate response against low pathogenic avian influenza virus infection.

Authors:  Hanaa Ahmed-Hassan; Mohamed Sarjoon Abdul-Cader; Upasama De Silva Senapathi; Maha Ahmed Sabry; Eman Hamza; Eva Nagy; Shayan Sharif; Mohamed Faizal Abdul-Careem
Journal:  Virol J       Date:  2018-03-12       Impact factor: 4.099

5.  The differential antiviral activities of chicken interferon α (ChIFN-α) and ChIFN-β are related to distinct interferon-stimulated gene expression.

Authors:  Hongren Qu; Limin Yang; Shanshan Meng; Lei Xu; Yuhai Bi; Xiaojuan Jia; Jing Li; Lei Sun; Wenjun Liu
Journal:  PLoS One       Date:  2013-03-19       Impact factor: 3.240

6.  Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster.

Authors:  G Lutfalla; S J Holland; E Cinato; D Monneron; J Reboul; N C Rogers; J M Smith; G R Stark; K Gardiner; K E Mogensen
Journal:  EMBO J       Date:  1995-10-16       Impact factor: 11.598

7.  Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and of an associated surface protein in response to IFN-alpha and IFN-beta.

Authors:  C Abramovich; L M Shulman; E Ratovitski; S Harroch; M Tovey; P Eid; M Revel
Journal:  EMBO J       Date:  1994-12-15       Impact factor: 11.598
  7 in total

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