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Literature DB >> 8026716

Action of alpha-momorcharin, a ribosome inactivating protein, on cultured tumor cell lines.

Abstract

1. alpha-Momorcharin, a glycoprotein isolated from seeds of the bitter gourd, Momordica charantia inhibited incorporation of [3H]thymidine, [3H]leucine and [3H]uridine into P388 (mouse monocyte-macrophage), J774 (Balb/c macrophage), JAR (human placental choriocarcinoma) and sarcoma S180 cell lines. 2. The most potent inhibitory effect was exerted on P388 cells and the smallest effect on sarcoma cells. 3. alpha-Momorcharin also enhanced the tumoricidal effect of mouse macrophages on mouse mastocytomal (P815) cells.

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Year: 1994 PMID： 8026716 DOI： 10.1016/0306-3623(94)90012-4

Source DB: PubMed Journal: Gen Pharmacol ISSN： 0306-3623

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Cited

6 in total

1. Preferential cytotoxicity of the type I ribosome inactivating protein alpha-momorcharin on human nasopharyngeal carcinoma cells under normoxia and hypoxia.

Authors: Wen Liang Pan; Jack Ho Wong; Evandro Fei Fang; Yau Sang Chan; Tzi Bun Ng; Randy Chi Fai Cheung
Journal: Biochem Pharmacol Date: 2014-03-14 Impact factor: 5.858

Review 2. Bitter melon: a panacea for inflammation and cancer.

Authors: Prasad R Dandawate; Dharmalingam Subramaniam; Subhash B Padhye; Shrikant Anant
Journal: Chin J Nat Med Date: 2016-02

3. Effect of α, β momorcharin on viability, caspase activity, cytochrome c release and on cytosolic calcium levels in different cancer cell lines.

Authors: Gunasekar Manoharan; Seema R Jaiswal; Jaipaul Singh
Journal: Mol Cell Biochem Date: 2013-12-03 Impact factor: 3.396

Action of alpha-momorcharin, a ribosome inactivating protein, on cultured tumor cell lines.

1. Preferential cytotoxicity of the type I ribosome inactivating protein alpha-momorcharin on human nasopharyngeal carcinoma cells under normoxia and hypoxia.

Review 2. Bitter melon: a panacea for inflammation and cancer.

3. Effect of α, β momorcharin on viability, caspase activity, cytochrome c release and on cytosolic calcium levels in different cancer cell lines.

4. Antileukemic Potential of Momordica charantia Seed Extracts on Human Myeloid Leukemic HL60 Cells.

5. Genomic discovery of the hypsin gene and biosynthetic pathways for terpenoids in Hypsizygus marmoreus.

6. A stable trypsin inhibitor from Chinese dull black soybeans with potentially exploitable activities.