Literature DB >> 8026706

Interactions of ginsenosides with ligand-bindings of GABA(A) and GABA(B) receptors.

T Kimura1, P A Saunders, H S Kim, H M Rheu, K W Oh, I K Ho.   

Abstract

1. Total saponin fraction decreased the affinity of specific [3H]muscimol binding without changes in Bmax. Ginsenoside Rb1 Rb2, Rc, Re, Rf and Rg1 inhibited the specific [3H]muscimol binding to the high-affinity site. 2. Total saponin fraction increased the affinity of specific [3H]flunitrazepam binding. Ginsenoside Re and Rf enhanced specific [3H]flunitrazepam binding. 3. Total saponin fraction decreased the affinity of specific [35S]TBPS binding without changes in Bmax. Ginsenosides did not affect specific or non-specific [35S]TBPS binding. 4. Total saponin fraction decreased the affinity of specific [3H]baclofen binding without changes in Bmax. Ginsenoside Rc inhibited specific [3H]baclofen binding.

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Year:  1994        PMID： 8026706     DOI： 10.1016/0306-3623(94)90032-9

Source DB:  PubMed          Journal:  Gen Pharmacol        ISSN： 0306-3623


  21 in total

1.  The nootropic properties of ginseng saponin Rb1 are linked to effects on anxiety.

Authors:  James D Churchill; Jennifer L Gerson; Kendra A Hinton; Jennifer L Mifek; Michael J Walter; Cynthia L Winslow; Richard A Deyo
Journal:  Integr Physiol Behav Sci       Date:  2002 Jul-Sep

2.  Activation of insulin-like growth factor I receptor-mediated pathway by ginsenoside Rg1.

Authors:  Wen-Fang Chen; Wai-Sum Lau; Pik-Yuen Cheung; De-An Guo; Man-Sau Wong
Journal:  Br J Pharmacol       Date:  2006-03       Impact factor: 8.739

3.  Effect of a polysaccharide fraction of ginseng root on learning and memory in rats (using an active escape response as an example).

Authors:  I I Lyubimov; V M Borzenkov; N E Chepurnova; S A Chepurnov
Journal:  Neurosci Behav Physiol       Date:  1997 Sep-Oct

Review 4.  What do most erectile dysfunction guidelines have in common? No evidence-based discussion or recommendation of heart-healthy lifestyle changes and/or Panax ginseng.

Authors:  Mark A Moyad; Kwangsung Park
Journal:  Asian J Androl       Date:  2012-09-24       Impact factor: 3.285

5.  Natural health product-drug interaction tool: A scoping review.

Authors:  Anastasia Kutt; Lauren Girard; Candace Necyk; Paula Gardiner; Heather Boon; Joanne Barnes; Sunita Vohra
Journal:  Can Pharm J (Ott)       Date:  2016-03-03

6.  Ginsenoside Rc and Rg1 differentially modulate NMDA receptor subunit mRNA levels after intracerebroventricular infusion in rats.

Authors:  H S Kim; S L Hwang; S Oh
Journal:  Neurochem Res       Date:  2000-08       Impact factor: 3.996

7.  Changes of [3H]MK-801, [3H]muscimol and [3H]flunitrazepam binding in rat brain by the prolonged ventricular infusion of transformed ginsenosides.

Authors:  Soyong Jang; Jong Hoon Ryu; Dong-Hyun Kim; Seikwan Oh
Journal:  Neurochem Res       Date:  2004-12       Impact factor: 3.996

8.  Effects of tissue-cultured mountain ginseng (Panax ginseng CA Meyer) extract on male patients with erectile dysfunction.

Authors:  Tae-Hwan Kim; Seung Hyun Jeon; Eun-Joo Hahn; Kee-Yoeup Paek; Jong Kwan Park; Nae Young Youn; Hyung-Lae Lee
Journal:  Asian J Androl       Date:  2009-02-23       Impact factor: 3.285

9.  Mitogen-activated protein kinase (MAPK) pathway mediates the oestrogen-like activities of ginsenoside Rg1 in human breast cancer (MCF-7) cells.

Authors:  Wai-Sum Lau; Wen-Fang Chen; Robbie Yat-Kan Chan; De-An Guo; Man-Sau Wong
Journal:  Br J Pharmacol       Date:  2009-03-09       Impact factor: 8.739

10.  Ginsenoside Rg1 protects dopaminergic neurons in a rat model of Parkinson's disease through the IGF-I receptor signalling pathway.

Authors:  Li Xu; Wen-Fang Chen; Man-Sau Wong
Journal:  Br J Pharmacol       Date:  2009-08-24       Impact factor: 8.739
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