Literature DB >> 8026513

Naive T cells can mediate delayed-type hypersensitivity response in T cell receptor transgenic mice.

T Sato1, T Sasahara, Y Nakamura, T Osaki, T Hasegawa, T Tadakuma, Y Arata, Y Kumagai, M Katsuki, S Habu.   

Abstract

We produced transgenic mice expressing T cell receptor-alpha beta chain genes, derived from the chicken ovalbumin (OVA)-specific I-Ad-restricted CD4+CD8- T helper cell clone 7-3-7. In transgenic mice with H-2d genetic background (Tg-d mice), delayed-type hypersensitivity (DTH) was induced in the hind footpad by one inoculation with OVA without any previous sensitization, suggesting that naive T cells have the potential to be involved in DTH response. Spleen cells from nonimmunized Tg-d mice showed a strong T cell proliferative response to in vitro stimulation with OVA. Furthermore, these spleen cells produce cytokines including interleukin(IL)-2, IL-3, interferon-gamma, granulocyte/macrophage colony-stimulating factor, macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta, which may play an important role in the attraction of mononuclear cells to an antigen-challenging site.

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Year:  1994        PMID： 8026513     DOI： 10.1002/eji.1830240708

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  16 in total

1.  Effect of specific antigen stimulation on intraepithelial lymphocyte migration to small intestinal mucosa.

Authors:  S Komoto; S Miura; S Koseki; M Goto; S Hachimura; H Fujimori; R Hokari; Y Hara; T Ogino; C Watanabe; H Nagata; S Kaminogawa; T Hibi; H Ishii
Journal:  Clin Exp Immunol       Date:  2005-05       Impact factor: 4.330

2.  Interleukin 12 and CD86 Regulate Th1 and Th2 Development Induced by a Range of Antigen Doses Presented by Peyer's Patch and Spleen Cells.

Authors:  Tadashi Yoshida; Satoshi Hachimura; Mina Ishimori; Wataru Ise; Mamoru Totsuka; Akio Ametani; Shuichi Kaminogawa
Journal:  Cytotechnology       Date:  2003-11       Impact factor: 2.058

3.  Dendritic Cells from Spleen, Mesenteric Lymph Node and Peyer's Patch Can Induce the Production of Both IL-4 and IFN-gamma from Primary Cultures of Naive CD4(+) T Cells in a Dose-Dependent Manner.

Authors:  Masanobu Hibi; Satoshi Hachimura; Wataru Ise; Ayuko Sato; Tadashi Yoshida; Tsuyoshi Takayama; Kastumi Sasaki; Takashi Senga; Shuichi Hashizume; Mamoru Totsuka; Shuichi Kaminogawa
Journal:  Cytotechnology       Date:  2003-11       Impact factor: 2.058

4.  Th2 polarization enhanced by oral administration of higher doses of antigen.

Authors:  M Hashiguchi; S Hachimura; A Ametani; S Kaminogawa
Journal:  Cytotechnology       Date:  2000-07       Impact factor: 2.058

5.  Posttranslational modification of the glycosylation inhibiting factor (GIF) gene product generates bioactive GIF.

Authors:  H Watarai; R Nozawa; A Tokunaga; N Yuyama; M Tomas; A Hinohara; K Ishizaka; Y Ishii
Journal:  Proc Natl Acad Sci U S A       Date:  2000-11-21       Impact factor: 11.205

6.  Increased susceptibility to airway responses in CD40-deficient mice.

Authors:  H Takahashi; S Ebihara; A Kanda; M Kamanaka; T Sato; S Habu; H Kikutani; H Sasaki
Journal:  Clin Exp Immunol       Date:  2003-07       Impact factor: 4.330

7.  Amaranth Grain Inhibits Antigen-Specific IgE Production Through Augmentation of the IFN-gamma Response in vivo and in vitro.

Authors:  Masanobu Hibi; Satoshi Hachimura; Shuichi Hashizume; Takahide Obata; Shuichi Kaminogawa
Journal:  Cytotechnology       Date:  2003-11       Impact factor: 2.058

8.  Orally tolerant CD4 T cells respond poorly to antigenic stimulation but strongly to direct stimulation of intracellular signaling pathways.

Authors:  K Asai; S Hachimura; T Toraya; S Kaminogawa
Journal:  Cytotechnology       Date:  2001-07       Impact factor: 2.058

9.  Dietary nucleotides increase the mucosal IgA response and the secretion of transforming growth factor beta from intestinal epithelial cells in mice.

Authors:  Shinya Nagafuchi; Mamoru Totsuka; Satoshi Hachimura; Masao Goto; Takeshi Takahashi; Takaji Yajima; Tamotsu Kuwata; Shuichi Kaminogawa
Journal:  Cytotechnology       Date:  2002-11       Impact factor: 2.058

10.  Murine Peyer's patch dendritic cells prime naïve CD4(+) T cells to produce interferon-gamma.

Authors:  Ayuko Sato; Masaaki Hashiguchi; Satoshi Hachimura; Shuichi Kaminogawa
Journal:  Cytotechnology       Date:  2002-11       Impact factor: 2.058
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