Literature DB >> 8026358

Xenobiotic metabolism in idiopathic Parkinson's disease in Nigerian Africans.

E Igbokwe1, A O Ogunniyi, B O Osuntokun.   

Abstract

The acetylator phenotype using sulphadimidine as a probe drug was studied in 20 idiopathic Parkinson's disease (IPD) patients and 21 control subjects. 10(50%) of the IPD patients belonged to the slow acetylator phenotype but this did not differ significantly from the proportion 7 (33%) of control subjects who were slow acetylators. The result does not suggest a role for acetylation in the aetiopathogenesis of IPD in Nigerian African.

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Year:  1993        PMID: 8026358

Source DB:  PubMed          Journal:  East Afr Med J        ISSN: 0012-835X


  3 in total

Review 1.  Parkinson's disease in Nigeria: A review of published studies and recommendations for future research.

Authors:  Oluwafemi G Oluwole; Helena Kuivaniemi; Jonathan A Carr; Owen A Ross; Matthew O B Olaogun; Soraya Bardien; Morenikeji A Komolafe
Journal:  Parkinsonism Relat Disord       Date:  2018-12-08       Impact factor: 4.891

2.  Comparison of CYP1A2 and NAT2 phenotypes between black and white smokers.

Authors:  Joshua E Muscat; Brian Pittman; Wayne Kleinman; Philip Lazarus; Steven D Stellman; John P Richie
Journal:  Biochem Pharmacol       Date:  2008-07-25       Impact factor: 5.858

3.  N-acetyltransferase 2 (NAT2) gene polymorphisms in Parkinson's disease.

Authors:  Juergen Borlak; Stella Marie Reamon-Buettner
Journal:  BMC Med Genet       Date:  2006-03-29       Impact factor: 2.103

  3 in total

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