| Literature DB >> 8026215 |
B M Conti-Tronconi1, K E McLane, M A Raftery, S A Grando, M P Protti.
Abstract
The nicotinic acetylcholine receptors (AChR) are presently the best-characterized neurotransmitter receptors. They are pentamers of homologous or identical subunits, symmetrically arranged to form a transmembrane cation channel. The AChR subunits form a family of homologous proteins, derived from a common ancestor. An autoimmune response to muscle AChR causes the disease myasthenia gravis. This review summarizes recent developments in the understanding of the AChR structure and its molecular recognition by the immune system in myasthenia.Entities:
Mesh：
Substances：
Year: 1994 PMID： 8026215 DOI： 10.3109/10409239409086798
Source DB: PubMed Journal: Crit Rev Biochem Mol Biol ISSN： 1040-9238 Impact factor: 8.250