Literature DB >> 8025703

Oxygen radicals in focal cerebral ischemia.

P H Chan1.   

Abstract

Oxygen free radicals have been widely implicated in the pathogenesis of brain injury due to ischemia followed by reperfusion. The success of making transgenic animals overexpressing human CuZn-superoxide dismutase (CuZn-SOD) in brain cells allows researchers to discern the specific role of superoxide radicals in reperfusion injury after focal ischemia. It has been shown that increased brain levels of CuZn-SOD in transgenic mice protect neurons from ischemia/reperfusion injury. However, overexpression of CuZn-SOD does not provide neuronal protection in permanent focal ischemia in mice, when compared with non-transgenic mouse littermates. It is proposed that molecular genetic approaches of modifying antioxidant levels in the brain offer a unique tool for studying oxidative mechanisms in focal cerebral ischemia.

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Year:  1994        PMID： 8025703     DOI： 10.1111/j.1750-3639.1994.tb00811.x

Source DB:  PubMed          Journal:  Brain Pathol        ISSN： 1015-6305            Impact factor:   6.508


  55 in total

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Review 5.  The neurovascular unit and combination treatment strategies for stroke.

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7.  MRI blood-brain barrier permeability measurements to predict hemorrhagic transformation in a rat model of ischemic stroke.

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8.  Translational research using a mouse model of intracranial aneurysm.

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9.  Nanoparticles for targeted delivery of antioxidant enzymes to the brain after cerebral ischemia and reperfusion injury.

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10.  Alterations of oxidative stress markers and apoptosis markers in the striatum after transient focal cerebral ischemia in rats.

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