Literature DB >> 8024809

Expanding horizons for receptors coupled to G proteins: diversity and disease.

S R Coughlin1.   

Abstract

The known repertoire of seven transmembrane domain receptors coupled to G proteins has expanded in several interesting directions. Both loss-of-function and activating mutations have been found at the root of a variety of diseases. More will undoubtedly be uncovered. The diversity of ligands which trigger G protein coupled receptors continues to grow, and with it the variety of known strategies for ligand detection. These and other developments promise continued excitement in this field.

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Year:  1994        PMID： 8024809     DOI： 10.1016/0955-0674(94)90135-x

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  24 in total

1.  Melanocortin-1 receptor polymorphisms and risk of melanoma: is the association explained solely by pigmentation phenotype?

Authors:  J S Palmer; D L Duffy; N F Box; J F Aitken; L E O'Gorman; A C Green; N K Hayward; N G Martin; R A Sturm
Journal:  Am J Hum Genet       Date:  2000-01       Impact factor: 11.025

2.  Melanocortin-1 receptor variant R151C modifies melanoma risk in Dutch families with melanoma.

Authors:  P A van der Velden; L A Sandkuijl; W Bergman; S Pavel; L van Mourik; R R Frants; N A Gruis
Journal:  Am J Hum Genet       Date:  2001-08-07       Impact factor: 11.025

Review 3.  Genetic variations in human G protein-coupled receptors: implications for drug therapy.

Authors:  W Sadee; E Hoeg; J Lucas; D Wang
Journal:  AAPS PharmSci       Date:  2001

4.  The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor has broad signaling effects in primary effusion lymphoma cells.

Authors:  Mark Cannon; Nicola J Philpott; Ethel Cesarman
Journal:  J Virol       Date:  2003-01       Impact factor: 5.103

5.  Mutational analysis and molecular modeling of the nonapeptide hormone binding domains of the [Arg8]vasotocin receptor.

Authors:  H Hausmann; A Richters; H J Kreienkamp; W Meyerhof; H Mattes; K Lederis; H Zwiers; D Richter
Journal:  Proc Natl Acad Sci U S A       Date:  1996-07-09       Impact factor: 11.205

6.  KSHV G protein-coupled receptor inhibits lytic gene transcription in primary-effusion lymphoma cells via p21-mediated inhibition of Cdk2.

Authors:  Mark Cannon; Ethel Cesarman; Chris Boshoff
Journal:  Blood       Date:  2005-09-08       Impact factor: 22.113

7.  Dominant-negative mutations in the G-protein-coupled alpha-factor receptor map to the extracellular ends of the transmembrane segments.

Authors:  M Dosil; L Giot; C Davis; J B Konopka
Journal:  Mol Cell Biol       Date:  1998-10       Impact factor: 4.272

Review 8.  Review: amino acid domains involved in constitutive activation of G-protein-coupled receptors.

Authors:  P J Pauwels; T Wurch
Journal:  Mol Neurobiol       Date:  1998       Impact factor: 5.590

9.  Molecular Architecture of G Protein-Coupled Receptors.

Authors:  A Michiel van Rhee; Kenneth A Jacobson
Journal:  Drug Dev Res       Date:  1996-01-01       Impact factor: 4.360

10.  Truncated, desensitization-defective neurokinin receptors mediate sustained MAP kinase activation, cell growth and transformation by a Ras-independent mechanism.

Authors:  J Alblas; I van Etten; W H Moolenaar
Journal:  EMBO J       Date:  1996-07-01       Impact factor: 11.598
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