Literature DB >> 8023644

High-dose recombinant human erythropoietin and low-dose corticosteroids for treatment of anemia in paroxysmal nocturnal hemoglobinuria.

K Bourantas1.   

Abstract

Three patients with paroxysmal nocturnal hemoglobinuria (PNH) and severe anemia were treated with high-dose recombinant human erythropoietin (rHEpo) and low-dose corticosteroids. During therapy their hemoglobin levels gradually improved and no blood transfusions were required. Neither rHEpo nor corticosteroids caused any side effects. This study shows that high rHEpo and low corticosteroid doses may improve the anemia of PNH patients.

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Year:  1994        PMID： 8023644     DOI： 10.1159/000204254

Source DB:  PubMed          Journal:  Acta Haematol        ISSN： 0001-5792            Impact factor:   2.195


  9 in total

Review 1.  Diagnosis and management of paroxysmal nocturnal hemoglobinuria.

Authors:  Charles Parker; Mitsuhiro Omine; Stephen Richards; Jun-Ichi Nishimura; Monica Bessler; Russell Ware; Peter Hillmen; Lucio Luzzatto; Neal Young; Taroh Kinoshita; Wendell Rosse; Gerard Socié
Journal:  Blood       Date:  2005-07-28       Impact factor: 22.113

2.  Paroxysmal nocturnal hemoglobinuria clones in severe aplastic anemia patients treated with horse anti-thymocyte globulin plus cyclosporine.

Authors:  Phillip Scheinberg; Michael Marte; Olga Nunez; Neal S Young
Journal:  Haematologica       Date:  2010-07       Impact factor: 9.941

Review 3.  Management issues in paroxysmal nocturnal hemoglobinuria.

Authors:  Gabrielle Meyers; Charles J Parker
Journal:  Int J Hematol       Date:  2003-02       Impact factor: 2.490

Review 4.  Recent advances in biological and clinical aspects of paroxysmal nocturnal hemoglobinuria.

Authors:  Lucio Luzzatto; Giacomo Gianfaldoni
Journal:  Int J Hematol       Date:  2006-08       Impact factor: 2.490

5.  Paroxysmal nocturnal hemoglobinuria: pathophysiology, natural history and treatment options in the era of biological agents.

Authors:  Antonio M Risitano; Bruno Rotoli
Journal:  Biologics       Date:  2008-06

Review 6.  Controversies in selection of epoetin dosages. Issues and answers.

Authors:  P Zachée
Journal:  Drugs       Date:  1995-04       Impact factor: 9.546

7.  Evaluation of danazol, cyclosporine, and prednisolone as single agent or in combination for paroxysmal nocturnal hemoglobinuria.

Authors:  Kanjaksha Ghosh; Manisha Madkaikar; Maya Gupta; Farah Jijina
Journal:  Turk J Haematol       Date:  2013-12-05       Impact factor: 1.831

8.  Characteristics of Taiwanese patients of PNH in the international PNH registry.

Authors:  Wen-Chien Chou; Wei-Han Huang; Ming-Chung Wang; Chao-Sung Chang; Shih-Peng Yeh; Tzeon-Jye Chiou; Yeu-Chin Chen; Tseng-Hsi Lin; Ming-Ching Shen
Journal:  Thromb J       Date:  2016-10-04

9.  Classical Paroxysmal Nocturnal Hemoglobinuria Presenting With Severe Anemia and Pigmented Acute Kidney Injury.

Authors:  Mohith H N; Christopher J Pinto; Jana Poornima; Ajay K Rajput; Marziyeh Bagheri; Basawantrao Patil; Mohammad Nizamuddin
Journal:  Cureus       Date:  2022-08-26
  9 in total

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