Literature DB >> 8021653

Structure of malhamensilipin A, an inhibitor of protein tyrosine kinase, from the cultured chrysophyte Poterioochromonas malhamensis.

J L Chen1, P J Proteau, M A Roberts, W H Gerwick, D L Slate, R H Lee.   

Abstract

A new chlorosulfolipid, malhamensilpin A [1] was isolated from the cultured chrysophyte Poterioochromonas malhamensis. Malhamensilipin A was demonstrated to be a modest inhibitor of pp60v-src protein tyrosine kinase. The structure was determined by detailed spectral analysis to be a novel C24 hexachloro lipid containing a vinyl sulfate ester (2,11,12,13,15,16-hexachloro-14-hydroxy-n-tetracos-1E-enol-1-sulfa te).

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 8021653     DOI： 10.1021/np50106a015

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  12 in total

1.  INTEGRATED APPROACHES TO THE CONFIGURATIONAL ASSIGNMENT OF MARINE NATURAL PRODUCTS.

Authors:  Tadeusz F Molinski; Brandon I Morinaka
Journal:  Tetrahedron       Date:  2012-11-18       Impact factor: 2.457

2.  Approaches to the chemical synthesis of the chlorosulfolipids.

Authors:  Won-Jin Chung; Christopher D Vanderwal
Journal:  Acc Chem Res       Date:  2014-01-08       Impact factor: 22.384

Review 3.  Chlorosulfolipids: structure, synthesis, and biological relevance.

Authors:  D Karl Bedke; Christopher D Vanderwal
Journal:  Nat Prod Rep       Date:  2010-12-02       Impact factor: 13.423

4.  A concise enantioselective synthesis of the chlorosulfolipid malhamensilipin A.

Authors:  D Karl Bedke; Grant M Shibuya; Alban R Pereira; William H Gerwick; Christopher D Vanderwal
Journal:  J Am Chem Soc       Date:  2010-03-03       Impact factor: 15.419

5.  Catalytic Enantioselective Dihalogenation and the Selective Synthesis of (-)-Deschloromytilipin A and (-)-Danicalipin A.

Authors:  Matthew L Landry; Dennis X Hu; Grace M McKenna; Noah Z Burns
Journal:  J Am Chem Soc       Date:  2016-04-08       Impact factor: 15.419

6.  Mollenyne A, a long-chain chlorodibromohydrin amide from the sponge Spirastrella mollis.

Authors:  Brandon I Morinaka; Tadeusz F Molinski
Journal:  Org Lett       Date:  2011-11-16       Impact factor: 6.005

7.  Total synthesis of a chlorosulpholipid cytotoxin associated with seafood poisoning.

Authors:  Christian Nilewski; Roger W Geisser; Erick M Carreira
Journal:  Nature       Date:  2009-01-29       Impact factor: 49.962

8.  Structure revision and absolute configuration of malhamensilipin A from the freshwater chrysophyte Poterioochromonas malhamensis.

Authors:  Alban R Pereira; Tara Byrum; Grant M Shibuya; Christopher D Vanderwal; William H Gerwick
Journal:  J Nat Prod       Date:  2010-02-26       Impact factor: 4.050

9.  A synthesis of the chlorosulfolipid mytilipin A via a longest linear sequence of seven steps.

Authors:  Won-Jin Chung; Joseph S Carlson; D Karl Bedke; Christopher D Vanderwal
Journal:  Angew Chem Int Ed Engl       Date:  2013-08-08       Impact factor: 15.336

10.  General approach to the synthesis of the chlorosulfolipids danicalipin A, mytilipin A, and malhamensilipin A in enantioenriched form.

Authors:  Won-jin Chung; Joseph S Carlson; Christopher D Vanderwal
Journal:  J Org Chem       Date:  2014-02-13       Impact factor: 4.354
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.