| Literature DB >> 8021608 |
M M Willcocks1, T D Brown, C R Madeley, M J Carter.
Abstract
We have determined the complete genomic sequence of human astrovirus serotype 1 isolated in Newcastle upon Tyne. The genome is 6813 nucleotides long and contains three sequential open reading frames (ORFs). The two closest to the 5' end are linked by a ribosomal frameshifting motif and contain sequence motifs indicative of non-structural virus proteins: serine protease and RNA-dependent RNA polymerase. A nuclear addressing sequence is also located here. The 3' ORF encodes the virion structural polypeptides as a polyprotein precursor. This genomic organization resembles that of the plant virus family Luteoviridae.Entities:
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Year: 1994 PMID： 8021608 DOI： 10.1099/0022-1317-75-7-1785
Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891