| Literature DB >> 8021605 |
M Sakamoto1, Y Akahane, F Tsuda, T Tanaka, D G Woodfield, H Okamoto.
Abstract
The entire nucleotide sequence of a hepatitis C virus (HCV) genome (NZL1) of genotype V/3a was determined from overlapping cDNA clones obtained from a human carrier in New Zealand. It comprised 9425 nucleotides (nt) including a 5'-untranslated region of 339 nt, a single large open reading frame encoding a polyprotein of 3021 amino acids, a 3'-untranslated region of 23 nt, and 3'-terminal poly(U) stretches of variable lengths. The NZL1 genome was compared with 15 HCV isolates of other genotypes for which the full-length sequence has been determined. It differed from them by 31.1 to 34.3% in nucleotide sequence identity and by 24.5 to 29.1% in amino acid sequence identity, confirming the distinction of genotype V/3a from the other isolates.Entities:
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Year: 1994 PMID： 8021605 DOI： 10.1099/0022-1317-75-7-1761
Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891