N Lawrence1, W I Cottel. 1. University of Medicine & Dentistry of New Jersey, Cooper Hospital, Camden.
Abstract
BACKGROUND: Perineural invasion of squamous cell carcinoma of the skin causes increased mortality. OBJECTIVE: We compared survival rates for treatment with Mohs surgery with previous studies of conventional surgery and postoperative radiotherapy. METHODS: With a computerized tumor registry we identified 44 cases of squamous cell carcinoma with perineural invasion recurrence, and hazard rates were calculated. RESULTS: Of 44 patients treated with Mohs surgery, three had recurrences. On this basis a survival probability of 88.7% was calculated. Calculation of hazard rate showed highest probability of recurrence 3 to 6 years after Mohs surgery. The clinical characteristics associated with perineural tumor invasion were male sex, size of tumor (> 2 cm), forehead location, and previous therapy. CONCLUSION: When compared with conventional surgical excision and postoperative radiotherapy, early detection and treatment by Mohs surgery of squamous cell carcinoma with perineural invasion result in a much improved survival probability.
BACKGROUND: Perineural invasion of squamous cell carcinoma of the skin causes increased mortality. OBJECTIVE: We compared survival rates for treatment with Mohs surgery with previous studies of conventional surgery and postoperative radiotherapy. METHODS: With a computerized tumor registry we identified 44 cases of squamous cell carcinoma with perineural invasion recurrence, and hazard rates were calculated. RESULTS: Of 44 patients treated with Mohs surgery, three had recurrences. On this basis a survival probability of 88.7% was calculated. Calculation of hazard rate showed highest probability of recurrence 3 to 6 years after Mohs surgery. The clinical characteristics associated with perineural tumor invasion were male sex, size of tumor (> 2 cm), forehead location, and previous therapy. CONCLUSION: When compared with conventional surgical excision and postoperative radiotherapy, early detection and treatment by Mohs surgery of squamous cell carcinoma with perineural invasion result in a much improved survival probability.
Authors: Yusuf Dundar; Richard B Cannon; Marcus M Monroe; Luke Oliver Buchmann; Jason Patrick Hunt Journal: J Neurol Surg B Skull Base Date: 2016-11-23
Authors: Sharifeh Farasat; Siegrid S Yu; Victor A Neel; Kishwer S Nehal; Thomas Lardaro; Martin C Mihm; David R Byrd; Charles M Balch; Joseph A Califano; Alice Y Chuang; William H Sharfman; Jatin P Shah; Paul Nghiem; Clark C Otley; Anthony P Tufaro; Timothy M Johnson; Arthur J Sober; Nanette J Liégeois Journal: J Am Acad Dermatol Date: 2011-01-20 Impact factor: 11.527