Effects of schizophrenia and prefrontal leukotomy on movement preparation and generation.

The purpose of this study was to investigate the ability of leukotomized and unleukotomized schizophrenic patients to use advance information in the process of movement preparation. Subjects participated in an aiming task in which movements could be defined on the basis of hand used to perform the task, and distance travelled to the target. Subjects were provided with full, partial, or no prior information about the upcoming movement by either precueing hand, distance, both hand and distance, or by providing no precue. The leukotomized and unleukotomized schizophrenic patients were able to use this advance information to facilitate the speed of their responses in much the same way as did subjects in a normal control group. These results are discussed in terms of models of movement preparation, and the role of the frontal lobes in schizophrenia and movement planning.