B Vikram1, S Mishra. 1. Department of Radiation Oncology, Beth Israel Medical Center, New York, New York.
Abstract
BACKGROUND: Patients with head and neck cancer treated surgically have a high local recurrence rate, unless the surgeon is able to obtain adequate margins of resection. In patients with positive margins, tumor control is suboptimal despite postoperative radiotherapy. METHODS: We treated 25 consecutive patients, who were at high risk for local recurrence by virtue of positive margins, by modest dose postoperative external-beam irradiation (median 60 Gy) followed by elective iodine 125 (I-125) implantation. RESULTS: With a median follow-up of 1.5 years (range 1-5 years), there were no instances of necrosis, and only one (4%) instance of a local recurrence. Six patients (24%) developed distant metastases. CONCLUSIONS: These results indicate that elective I-125 implantation as a part of postoperative radiotherapy is safe enough for a phase III study in patients with positive margins.
BACKGROUND:Patients with head and neck cancer treated surgically have a high local recurrence rate, unless the surgeon is able to obtain adequate margins of resection. In patients with positive margins, tumor control is suboptimal despite postoperative radiotherapy. METHODS: We treated 25 consecutive patients, who were at high risk for local recurrence by virtue of positive margins, by modest dose postoperative external-beam irradiation (median 60 Gy) followed by elective iodine 125 (I-125) implantation. RESULTS: With a median follow-up of 1.5 years (range 1-5 years), there were no instances of necrosis, and only one (4%) instance of a local recurrence. Six patients (24%) developed distant metastases. CONCLUSIONS: These results indicate that elective I-125 implantation as a part of postoperative radiotherapy is safe enough for a phase III study in patients with positive margins.
Authors: David Hu; Ontario D Lau; Linda Wang; Guanyu Wang; Dorthe Schaue; Li Zhu; Min Huang; Yuan Lin; Miranda Dennis; Elliot Abemayor; David A Elashoff; Steven M Dubinett; William H McBride; Sherven Sharma; Ben Wu; Maie A St John Journal: Arch Otolaryngol Head Neck Surg Date: 2012-04
Authors: Yuan Lin; Jie Luo; Weichao Eric Zhu; Minu Srivastava; Dorthe Schaue; David A Elashoff; Steven M Dubinett; Sherven Sharma; Benjamin Wu; Maie A St John Journal: Otolaryngol Head Neck Surg Date: 2014-05-13 Impact factor: 3.497
Authors: Yazeed Alhiyari; Jundong Shao; Albert Y Han; Amanda Miller; Jeffrey F Krane; Marie Luff; Milica Momcilovic; David Shackelford; Zhen Gu; Maie A St John Journal: Sci Rep Date: 2022-03-04 Impact factor: 4.379