| Literature DB >> 8020941 |
J W Xuan1, J Kowalski, A F Chambers, D T Denhardt.
Abstract
A cDNA clone was isolated from HL60 human promyelocyte cells on the basis of the induction of its cognate mRNA by the phorbol ester TPA (12-O-tetradecanoyl phorbol-13-acetate) in the presence of cycloheximide. Northern analysis showed a peak of induction of a 1.9-kb mRNA at 3-6 h after TPA addition. Sequence analysis revealed that this cDNA was likely a human homolog of yeast isopentenyl diphosphate:dimethylallyl diphosphate isomerase, an enzyme important for isoprenoid synthesis and the prenylation of proteins such as ras p21.Entities:
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Year: 1994 PMID： 8020941 DOI： 10.1006/geno.1994.1139
Source DB: PubMed Journal: Genomics ISSN： 0888-7543 Impact factor: 5.736