Literature DB >> 8020533

The metabolism of ethosuximide.

J S Millership1, J Mifsud, P S Collier.   

Abstract

The metabolism of the antiepileptic drug ethosuximide (3-ethyl-3-methylpyrollidine-2,5-dione) (I) in animals and humans is reviewed. Chiral aspects of the metabolism of ethosuximide are discussed. Clarification of the precise nature of the hydroxymetabolites of ethosuximide is presented.

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Year:  1993        PMID： 8020533     DOI： 10.1007/BF03190184

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  5 in total

1.  Identification of 2-ethyl-2-methyl-3-hydroxysuccinimide as a major metabolite of ethosuximide in humans.

Authors:  P G Preste; C E Westerman; N P Das; B J Wilder; J H Duncan
Journal:  J Pharm Sci       Date:  1974-03       Impact factor: 3.534

2.  Metabolism of ethosuximide.

Authors:  J R Goulet; A W Kinkel; T C Smith
Journal:  Clin Pharmacol Ther       Date:  1976-08       Impact factor: 6.875

3.  Urinary metabolites of 2-ethyl-2-methylsuccinimide (ethosuximide) studied by combined gas chromatography mass spectrometry.

Authors:  J E Pettersen
Journal:  Biomed Mass Spectrom       Date:  1978-11

4.  Nonstereoselective disposition of ethosuximide in humans.

Authors:  T Villén; L Bertilsson; F Sjöqvist
Journal:  Ther Drug Monit       Date:  1990-09       Impact factor: 3.681

5.  Metabolism of 2-ethyl-2-methylsuccinimide (ethosuximide) in the rat and human.

Authors:  M G Horning; C Stratton; J Nowlin; D J Harvey; R M Hill
Journal:  Drug Metab Dispos       Date:  1973 May-Jun       Impact factor: 3.922
  5 in total
  1 in total

Review 1.  Treatment and care of women with epilepsy before, during, and after pregnancy: a practical guide.

Authors:  Bruna Nucera; Francesco Brigo; Eugen Trinka; Gudrun Kalss
Journal:  Ther Adv Neurol Disord       Date:  2022-06-11       Impact factor: 6.430
  1 in total

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