Literature DB >> 8020063

A newly discovered pathway of melanin formation in cultured retinal pigment epithelium of cattle.

U Schraermeyer1, H Stieve.   

Abstract

According to a recent hypothesis the melanin granules in the retinal pigment epithelium of mammals originate from photosensory membrane degradation. To test this hypothesis the retinal pigment epithelium of cattle was kept in tissue culture and exposed to gold-labelled rod outer segments. Gold granules were later detected inside phagosomes, melanosomes and mature melanin granules. Tyrosinase, the key enzyme in melanogenesis, was additionally localized inside phagosomes. These results indicate that in cultured retinal pigment epithelium the matrix of the melanosome can originate from phagosomes. Therefore, the melanosome is a specialized lysosome.

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Year:  1994        PMID： 8020063     DOI： 10.1007/bf00306113

Source DB:  PubMed          Journal:  Cell Tissue Res        ISSN： 0302-766X            Impact factor:   5.249


  23 in total

1.  Superoxide dismutase of bovine and frog rod outer segments.

Authors:  M O Hall; D O Hall
Journal:  Biochem Biophys Res Commun       Date:  1975-12-01       Impact factor: 3.575

2.  Retinal pigment epithelium. Interrelations of endoplasmic reticulum and melanolysosomes in the black mouse and its beige mutant.

Authors:  A B Novikoff; P M Leuenberger; P M Novikoff; N Quintana
Journal:  Lab Invest       Date:  1979-02       Impact factor: 5.662

3.  Evidence of melanogenesis in porcine retinal pigment epithelial cells in vitro.

Authors:  C K Dorey; X Torres; T Swart
Journal:  Exp Eye Res       Date:  1990-01       Impact factor: 3.467

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Authors:  D Armstrong; E Connole; L Feeney; E R Berman
Journal:  J Neurochem       Date:  1978-10       Impact factor: 5.372

5.  Phagocytic activity of the pigmented retinal epithelium. III. Interaction between lysosomes and ingested polystyrene spheres.

Authors:  J G Hollyfield; A Ward
Journal:  Invest Ophthalmol       Date:  1974-12

6.  Free radical and enzymatic mechanisms for the generation of protein bound reducing moieties.

Authors:  J A Simpson; S P Gieseg; R T Dean
Journal:  Biochim Biophys Acta       Date:  1993-02-13

7.  Superoxide production by porcine retinal pigment epithelium in vitro.

Authors:  C K Dorey; G G Khouri; L A Syniuta; S A Curran; J J Weiter
Journal:  Invest Ophthalmol Vis Sci       Date:  1989-06       Impact factor: 4.799

8.  Localization of peroxidase activity in the retina and the retinal pigment epithelium of the Syrian golden hamster (Mesocricetus auratus).

Authors:  U Schraermeyer
Journal:  Comp Biochem Physiol B       Date:  1992-09

9.  Evidence for melanogenesis in the retinal pigment epithelium of adult cattle and golden hamster.

Authors:  U Schraermeyer
Journal:  Comp Biochem Physiol B       Date:  1992-10

10.  N-hydroxysulfosuccinimide active esters: bis(N-hydroxysulfosuccinimide) esters of two dicarboxylic acids are hydrophilic, membrane-impermeant, protein cross-linkers.

Authors:  J V Staros
Journal:  Biochemistry       Date:  1982-08-17       Impact factor: 3.162
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  5 in total

1.  Tyrosinase biosynthesis and trafficking in adult human retinal pigment epithelial cells.

Authors:  Sylvie Julien; Norbert Kociok; Florian Kreppel; Jürgen Kopitz; Stefan Kochanek; Antje Biesemeier; Petra Blitgen-Heinecke; Peter Heiduschka; Ulrich Schraermeyer
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2007-02-21       Impact factor: 3.117

2.  Melanin production by a filamentous soil fungus in response to copper and localization of copper sulfide by sulfide-silver staining.

Authors:  T Caesar-Tonthat; K F Van Ommen; G G Geesey; J M Henson
Journal:  Appl Environ Microbiol       Date:  1995-05       Impact factor: 4.792

3.  Age, lipofuscin and melanin oxidation affect fundus near-infrared autofluorescence.

Authors:  Tatjana Taubitz; Yuan Fang; Antje Biesemeier; Sylvie Julien-Schraermeyer; Ulrich Schraermeyer
Journal:  EBioMedicine       Date:  2019-10-21       Impact factor: 8.143

4.  Proteomic and phototoxic characterization of melanolipofuscin: correlation to disease and model for its origin.

Authors:  Sarah Warburton; Wayne E Davis; Katie Southwick; Huijun Xin; Adam T Woolley; Gregory F Burton; Craig D Thulin
Journal:  Mol Vis       Date:  2007-03-01       Impact factor: 2.367

5.  Ultrastructural alterations in the retinal pigment epithelium and photoreceptors of a Stargardt patient and three Stargardt mouse models: indication for the central role of RPE melanin in oxidative stress.

Authors:  Tatjana Taubitz; Alexander V Tschulakow; Marina Tikhonovich; Barbara Illing; Yuan Fang; Antje Biesemeier; Sylvie Julien-Schraermeyer; Ulrich Schraermeyer
Journal:  PeerJ       Date:  2018-07-19       Impact factor: 2.984
  5 in total

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