| Literature DB >> 8019967 |
R B van Ooteghem1, E M Smit, A Beishuizen, A C Lambrechts, M vd Blij-Philipsen, T J Smilde, A Hagemeijer.
Abstract
A cell line named ROS-50 (Rotterdam suspension cell line no. 50) has been established from peripheral blood of a 69-year-old male with acute lymphoblastic leukemia (FAB type L3). Among the aberrations, cytogenetic analysis showed the presence of 14q+, 18q-, and two 8q- marker chromosomes. With fluorescence in situ hybridization (FISH) we characterized the chromosomal translocations, t(8;14) and t(14;18), in which the same chromosome 14 is involved. PCR analysis demonstrated the presence of on IGH-BCL2 rearrangement with a breakpoint in the minor cluster region (mcr) confirming the t(14;18) characteristic for follicular lymphoma. Additional studies showed high expression of BCL2 protein, an early B-cell immunophenotype, and an unusual pattern of IGH gene rearrangement.Entities:
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Year: 1994 PMID： 8019967 DOI： 10.1016/0165-4608(94)90003-5
Source DB: PubMed Journal: Cancer Genet Cytogenet ISSN： 0165-4608